Cell Biology Antibodies 8

Anti-CD24 Antibody (CAB2207)

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SKU:
CAB2207
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CD24 Antibody
Antibody SKU:CAB2207
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CD24 (NP_037362.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:1000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:B cells, MCF7, SKOV3, Jurkat, Raji, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CD24 (NP_037362.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGRA MVAR LGLG LLLL ALLL PTQI YSSE TTTG TSSN SSQS TSNS GLAP NPTN ATTK AAGG ALQS TASL FVVS LSLL HLYS
Gene ID:100133941
Uniprot:P25063
Cellular Location:Cell membrane, GPI-anchor, Lipid-anchor
Calculated MW:8kDa
Observed MW:45kDa/70kDa
Synonyms:CD24, CD24A, CD24 molecule, CD247
Background:This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:CD24: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS). A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface. Belongs to the CD24 family.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor; Cell surface; Cell development/differentiation; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: cell surface; membrane; plasma membrane; lipid raft

Molecular Function:protein binding; signal transducer activity; protein tyrosine kinase activator activity; protein kinase binding

Biological Process: respiratory burst; axon guidance; cell migration; Wnt receptor signaling pathway; regulation of phosphorylation; B cell receptor transport into lipid raft; immune response-regulating cell surface receptor signaling pathway; chemokine receptor transport out of lipid raft; positive regulation of activated T cell proliferation; positive regulation of MAP kinase activity; cell activation; cholesterol homeostasis; cell-cell adhesion; elevation of cytosolic calcium ion concentration; response to estrogen stimulus; response to molecule of bacterial origin; regulation of MAPKKK cascade; negative regulation of transforming growth factor-beta3 production; T cell costimulation; regulation of epithelial cell differentiation; response to hypoxia; regulation of cytokine and chemokine mediated signaling pathway

Disease: Multiple Sclerosis, Susceptibility To

UniProt Code:P25063
NCBI GenInfo Identifier:143811372
NCBI Gene ID:
NCBI Accession:P25063.2
Molecular Weight:
NCBI Full Name:Signal transducer CD24
UniProt Protein Name:Signal transducer CD24
UniProt Synonym Protein Names:Small cell lung carcinoma cluster 4 antigen; CD_antigen: CD24
Protein Family:Signal transducer
UniProt Gene Name:CD24  
UniProt Entry Name:CD24_HUMAN
Anti-CD24 Antibody (CAB2207)Western blot analysis of extracts of various cell lines, using CD24 antibody (CAB2207) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-CD24 Antibody (CAB2207)Immunohistochemistry of paraffin-embedded mouse spleen using CD24 Rabbit pAb (CAB2207) at dilution of 1:100 (40x lens).
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