Cell Biology Antibodies 1

Anti-CD226 Antibody (CAB10282)

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SKU:
CAB10282
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CD226 Antibody
Antibody SKU:CAB10282
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 19-254 of human CD226 (NP_006557.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 19-254 of human CD226 (NP_006557.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EEVL WHTS VPFA ENMS LECV YPSM GILT QVEW FKIG TQQD SIAI FSPT HGMV IRKP YAER VYFL NSTM ASNN MTLF FRNA SEDD VGYY SCSL YTYP QGTW QKVI QVVQ SDSF EAAV PSNS HIVS EPGK NVTL TCQP QMTW PVQA VRWE KIQP RQID LLTY CNLV HGRN FTSK FPRQ IVSN CSHG RWSV IVIP DVTV SDSG LYRC YLQA SAGE NETF VMRL TVAE GKTD NQYT LFVA
Gene ID:10666
Uniprot:Q15762
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:38kDa
Observed MW:65kDa
Synonyms:CD226, DNAM-1, DNAM1, PTA1, TLiSA1
Background:This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:DNAM-1: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.
UniProt Protein Details:

Protein type:Membrane protein, integral; Immunoglobulin superfamily; Cell adhesion

Chromosomal Location of Human Ortholog: 18q22.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; external side of plasma membrane; lipid raft

Molecular Function:integrin binding; protein binding; cell adhesion molecule binding; protein kinase binding

Biological Process: regulation of immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of immunoglobulin mediated immune response; cytokine production; cell recognition; positive regulation of natural killer cell mediated cytotoxicity; cell adhesion; signal transduction; positive regulation of mast cell activation

NCBI Summary:This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008]
UniProt Code:Q15762
NCBI GenInfo Identifier:317373338
NCBI Gene ID:10666
NCBI Accession:Q15762.2
UniProt Secondary Accession:Q15762,B2R818,
UniProt Related Accession:Q15762
Molecular Weight:
NCBI Full Name:CD226 antigen
NCBI Synonym Full Names:CD226 molecule
NCBI Official Symbol:CD226  
NCBI Official Synonym Symbols:PTA1; DNAM1; DNAM-1; TLiSA1  
NCBI Protein Information:CD226 antigen; adhesion glycoprotein; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; T lineage-specific activation antigen 1 antigen
UniProt Protein Name:CD226 antigen
UniProt Synonym Protein Names:DNAX accessory molecule 1
Protein Family:CD226 antigen
UniProt Gene Name:CD226  
UniProt Entry Name:CD226_HUMAN
Anti-CD226 Antibody (CAB10282)Western blot analysis of extracts of mouse lung, using CD226 antibody (CAB10282) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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