Immunology Antibodies 3
Anti-CD200R1 Antibody (CAB8278)
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- SKU:
- CAB8278
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | CD200R1 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8278 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 249-348 of human CD200R1 (NP_620161.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-937, NCI-H460 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 249-348 of human CD200R1 (NP_620161.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SLYI ELLP VPGA KKSA KLYI PYII LTII ILTI VGFI WLLK VNGC RKYK LNKT ESTP VVEE DEMQ PYAS YTEK NNPL YDTT NKVK ASEA LQSE VDTD LHTL |
| Gene ID: | 131450 |
| Uniprot: | Q8TD46 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein, Single-pass type I membrane protein |
| Calculated MW: | 18kDa/21kDa/36kDa/39kDa |
| Observed MW: | 45kDa |
| Synonyms: | CD200R1, CD200R, HCRTR2, MOX2R, OX2R |
| Background: | This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | CD200R: Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. Belongs to the CD200R family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 3q13.2 Cellular Component: plasma membrane; receptor complex Molecular Function:protein binding Biological Process: regulation of immune response |
| NCBI Summary: | This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8TD46 |
| NCBI GenInfo Identifier: | 26006823 |
| NCBI Gene ID: | 131450 |
| NCBI Accession: | Q8TD46.2 |
| UniProt Secondary Accession: | Q8TD46,Q52LJ7, Q6IS95, Q6UW94, Q6WHB8, Q8TD44, Q8TD45 Q8TD52, B3KWZ9, E9PCM9, |
| UniProt Related Accession: | Q8TD46 |
| Molecular Weight: | 39,056 Da |
| NCBI Full Name: | Cell surface glycoprotein CD200 receptor 1 |
| NCBI Synonym Full Names: | CD200 receptor 1 |
| NCBI Official Symbol: | CD200R1 |
| NCBI Official Synonym Symbols: | OX2R; MOX2R; CD200R; HCRTR2 |
| NCBI Protein Information: | cell surface glycoprotein CD200 receptor 1 |
| UniProt Protein Name: | Cell surface glycoprotein CD200 receptor 1 |
| UniProt Synonym Protein Names: | CD200 cell surface glycoprotein receptor; Cell surface glycoprotein OX2 receptor 1 |
| Protein Family: | Cell surface glycoprotein CD200 receptor |
| UniProt Gene Name: | CD200R1 |
| UniProt Entry Name: | MO2R1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CD200R1 antibody (CAB8278) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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