Immunology Antibodies 3

Anti-CD20 Antibody (CAB4893)

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SKU:
CAB4893
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
B1
Synonyms:
Bp35
Synonyms:
CD20
Synonyms:
CVID5
Synonyms:
LEU-16
Synonyms:
MS4A2
Synonyms:
S7
Research Area:
Immunology

Description

Product Name:CD20 Rabbit mAb
Product Code:CAB4893
Size:20uL, 50uL, 100uL
Synonyms:B1, Bp35, CD20, CVID5, LEU-16, MS4A2, S7
Applications:WB, IHC, IF
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CD20
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:A-549, Raji, U-937
Immunogen:A synthesized peptide derived from human CD20
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:931
Uniprot:P11836
Cellular Location:Cell membrane, Lipid-anchor, Multi-pass membrane protein
Calculated MW:33kDa
Observed MW:30-50KDa
UniProt Protein Function:MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell surface; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane

Molecular Function:epidermal growth factor receptor binding

Biological Process: B cell proliferation; humoral immune response

Disease: Immunodeficiency, Common Variable, 5

NCBI Summary:This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
UniProt Code:P11836
NCBI GenInfo Identifier:115968
NCBI Gene ID:931
NCBI Accession:P11836.1
UniProt Related Accession:P11836
Molecular Weight:
NCBI Full Name:B-lymphocyte antigen CD20
NCBI Synonym Full Names:membrane spanning 4-domains A1
NCBI Official Symbol:MS4A1  
NCBI Official Synonym Symbols:B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16  
NCBI Protein Information:B-lymphocyte antigen CD20
UniProt Protein Name:B-lymphocyte antigen CD20
UniProt Synonym Protein Names:B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20
Protein Family:CD209 antigen
UniProt Gene Name:MS4A1  
UniProt Entry Name:CD20_HUMAN
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