Immunology Antibodies 2

Anti-CD20 Antibody (CAB1793)

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SKU:
CAB1793
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-CD20 Antibody
Antibody SKU:CAB1793
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 208-297 of human CD20 (NP_068769.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:COS-7, H125, Mouse thymus, Mouse liver, Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 208-297 of human CD20 (NP_068769.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IAGI VENE WKRT CSRP KSNI VLLS AEEK KEQT IEIK EEVV GLTE TSSQ PKNE EDIE IIPI QEEE EEET ETNF PEPP QDQE SSPI ENDS SP
Gene ID:931
Uniprot:P11836
Cellular Location:Cell membrane, Lipid-anchor, Multi-pass membrane protein
Calculated MW:14kDa/33kDa
Observed MW:37kDa
Synonyms:MS4A1, B1, Bp35, CD20, CVID5, LEU-16, MS4A2, S7
Background:This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
UniProt Protein Function:MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell surface; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane

Molecular Function:epidermal growth factor receptor binding

Biological Process: B cell proliferation; humoral immune response

Disease: Immunodeficiency, Common Variable, 5

NCBI Summary:This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
UniProt Code:P11836
NCBI GenInfo Identifier:115968
NCBI Gene ID:931
NCBI Accession:P11836.1
UniProt Related Accession:P11836
Molecular Weight:
NCBI Full Name:B-lymphocyte antigen CD20
NCBI Synonym Full Names:membrane spanning 4-domains A1
NCBI Official Symbol:MS4A1  
NCBI Official Synonym Symbols:B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16  
NCBI Protein Information:B-lymphocyte antigen CD20
UniProt Protein Name:B-lymphocyte antigen CD20
UniProt Synonym Protein Names:B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20
Protein Family:CD209 antigen
UniProt Gene Name:MS4A1  
UniProt Entry Name:CD20_HUMAN
Anti-CD20 Antibody (CAB1793)Western blot analysis of extracts of various cell lines, using CD20 Antibody (CAB1793) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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OverviewProduct Name:CD20 Rabbit mAbProduct Code:CAB4893Size:20uL, 50uL, 100uLSynonyms:B1, Bp35, CD20, CVID5, LEU-16, MS4A2, S7