Cell Biology Antibodies 9
Anti-CD2 Antibody (CAB5632)
(No reviews yet)
Write a Review
- SKU:
- CAB5632
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CD2 Antibody |
| Antibody SKU: | CAB5632 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 235-351 of human CD2 (NP_001758.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BxPC-3, LO2, Mouse thymus, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 235-351 of human CD2 (NP_001758.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TKRK KQRS RRND EELE TRAH RVAT EERG RKPH QIPA STPQ NPAT SQHP PPPP GHRS QAPS HRPP PPGH RVQH QPQK RPPA PSGT QVHQ QKGP PLPR PRVQ PKPP HGAA ENSL SPSS N |
| Gene ID: | 914 |
| Uniprot: | P06729 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 39kDa |
| Observed MW: | 60kDa |
| Synonyms: | CD2, LFA-2, SRBC, T11 |
| Background: |
| UniProt Protein Function: | CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral; Apoptosis Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: anchored to plasma membrane; cell surface; external side of plasma membrane; extracellular region; integral to plasma membrane; intercellular junction; internal side of plasma membrane; plasma membrane Molecular Function:protein binding; protein homodimerization activity; receptor activity; receptor binding Biological Process: apoptosis; cell surface receptor linked signal transduction; cell-cell adhesion; heterotypic cell-cell adhesion; leukocyte migration; lipid raft polarization; natural killer cell activation; positive regulation of myeloid dendritic cell activation; positive regulation of tumor necrosis factor production; regulation of T cell differentiation; T cell activation |
| NCBI Summary: | CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010] |
| UniProt Code: | P06729 |
| NCBI GenInfo Identifier: | 160370002 |
| NCBI Gene ID: | 914 |
| NCBI Accession: | P06729.2 |
| UniProt Secondary Accession: | P06729,Q96TE5, |
| UniProt Related Accession: | P06729 |
| Molecular Weight: | 39,448 Da |
| NCBI Full Name: | T-cell surface antigen CD2 |
| NCBI Synonym Full Names: | CD2 molecule |
| NCBI Official Symbol: | CD2 |
| NCBI Official Synonym Symbols: | T11; SRBC; LFA-2 |
| NCBI Protein Information: | T-cell surface antigen CD2 |
| UniProt Protein Name: | T-cell surface antigen CD2 |
| UniProt Synonym Protein Names: | Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD_antigen: CD2 |
| Protein Family: | CD2 |
| UniProt Gene Name: | CD2 |
| UniProt Entry Name: | CD2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CD2 antibody (CAB5632) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
View AllClose
Related Products
Anti-CD2 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0267)
system_update_altDatasheetOverviewSKU:
Anti-Human CD2 In Vivo Antibody - Ultra Low Endotoxin
OverviewProduct Name:Anti-Human CD2 In Vivo Antibody - Ultra Low EndotoxinProduct Code:IVMB0264Size:1 mg, 5 mg, 25 mg, 50 mg, 100 mgClone:</
Anti-Human CD2 (LO-CD2a) In Vivo Antibody - Low Endotoxin
OverviewProduct Name:Anti-Human CD2 (LO-CD2a) In Vivo Antibody - Low EndotoxinProduct Code:IVMB0262Size:1 mg, 5 mg, 25 mg, 50 mg, 100 mgClon
CD2 Monoclonal Antibody (CAB23527)
OverviewProduct Name:CD2 Monoclonal AntibodyProduct Code:CAB23527Reactivity:MouseApplications:Western blottingH