Immunology Antibodies 1

Anti-CD180 Antibody (CAB10226)

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SKU:
CAB10226
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-CD180 Antibody
Antibody SKU:CAB10226
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-220 of human CD180 (NP_005573.2).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human
Positive Samples:Raji, A-549, LO2, THP-1
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-220 of human CD180 (NP_005573.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:WDQM CIEK EANK TYNC ENLG LSEI PDTL PNTT EFLE FSFN FLPT IHNR TFSR LMNL TFLD LTRC QINW IHED TFQS HHQL STLV LTGN PLIF MAET SLNG PKSL KHLF LIQT GISN LEFI PVHN LENL ESLY LGSN HISS IKFP KDFP ARNL KVLD FQNN AIHY ISRE DMRS LEQA INLS LNFN GNNV KGIE LGAF D
Gene ID:4064
Uniprot:Q99467
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:74kDa
Observed MW:105kDa
Synonyms:CD180, LY64, Ly78, RP105
Background:CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.
UniProt Protein Function:CD180: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells. Belongs to the Toll-like receptor family.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q12.3

Cellular Component: integral to plasma membrane

Molecular Function:receptor activity

Biological Process: inflammatory response; positive regulation of lipopolysaccharide-mediated signaling pathway; toll-like receptor signaling pathway

NCBI Summary:CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]
UniProt Code:Q99467
NCBI GenInfo Identifier:296434437
NCBI Gene ID:4064
NCBI Accession:Q99467.2
UniProt Secondary Accession:Q99467,Q32MM5, B2R7Z7,
UniProt Related Accession:Q99467
Molecular Weight:74kDa
NCBI Full Name:CD180 antigen
NCBI Synonym Full Names:CD180 molecule
NCBI Official Symbol:CD180  
NCBI Official Synonym Symbols:LY64; Ly78; RP105  
NCBI Protein Information:CD180 antigen
UniProt Protein Name:CD180 antigen
UniProt Synonym Protein Names:Lymphocyte antigen 64; Radioprotective 105 kDa protein; CD_antigen: CD180
Protein Family:CD180 antigen
UniProt Gene Name:CD180  
Anti-CD180 Antibody (CAB10226)Western blot analysis of extracts of various cell lines, using CD180 antibody (CAB10226) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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