Cell Biology Antibodies 4
Anti-CD177 Antibody (CAB13597)
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- SKU:
- CAB13597
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CD177 Antibody |
| Antibody SKU: | CAB13597 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-285 of human CD177 (NP_065139.2). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-285 of human CD177 (NP_065139.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VSDL PRQW TPKN TSCD SGLG CQDT LMLI ESGP QVSL VLSK GCTE AKDQ EPRV TEHR MGPG LSLI SYTF VCRQ EDFC NNLV NSLP LWAP QPPA DPGS LRCP VCLS MEGC LEGT TEEI CPKG TTHC YDGL LRLR GGGI FSNL RVQG CMPQ PVCN LLNG TQEI GPVG MTEN CDMK DFLT CHRG TTIM THGN LAQE PTDW TTSN TEMC EVGQ VCQE TLLL LDVG LTST LVGT KGCS TVGA QNSQ KTTI HSAP PGV |
| Gene ID: | 57126 |
| Uniprot: | Q8N6Q3 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor |
| Calculated MW: | 15kDa/27kDa/46kDa |
| Observed MW: |
| Synonyms: | CD177, HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1, NB1GP |
| Background: | This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. |
| UniProt Protein Function: | CD177: Induced by CSF3 in resting granulocytes. Induced in patients with polycythemia vera (PV) and with essential thrombocythemia (ET). 3 isoforms of the human protein are produced by alternative splicing |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: plasma membrane Biological Process: blood coagulation; leukocyte migration |
| NCBI Summary: | This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q8N6Q3 |
| NCBI GenInfo Identifier: | 91208246 |
| NCBI Gene ID: | 57126 |
| NCBI Accession: | Q8N6Q3.2 |
| UniProt Secondary Accession: | Q8N6Q3,Q711Q2, Q8NCV9, Q96QH1, Q9HDA5, |
| UniProt Related Accession: | Q8N6Q3 |
| Molecular Weight: | 437 |
| NCBI Full Name: | CD177 antigen |
| NCBI Synonym Full Names: | CD177 molecule |
| NCBI Official Symbol: | CD177 |
| NCBI Official Synonym Symbols: | NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GP |
| NCBI Protein Information: | CD177 antigen; NB1 glycoprotein; cell surface receptor; human neutrophil alloantigen 2a; polycythemia rubra vera protein 1 |
| UniProt Protein Name: | CD177 antigen |
| UniProt Synonym Protein Names: | Human neutrophil alloantigen 2a; HNA-2a; NB1 glycoprotein; NB1 GP; Polycythemia rubra vera protein 1; PRV-1; CD_antigen: CD177 |
| Protein Family: | CD177 antigen |
| UniProt Gene Name: | CD177 |
| UniProt Entry Name: | CD177_HUMAN |
 | Immunofluorescence analysis of HeLa cells using CD177 antibody (CAB13597). Blue: DAPI for nuclear staining. |
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