Immunology Antibodies 3

Anti-CD163 Antibody (CAB8383)

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SKU:
CAB8383
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:Anti-CD163 Antibody
Antibody SKU:CAB8383
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 750-1050 of human CD163 (NP_004235.4).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:1000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, SW480
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 750-1050 of human CD163 (NP_004235.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LSDA HVVC RQLG CGEA INAT GSAH FGEG TGPI WLDE MKCN GKES RIWQ CHSH GWGQ QNCR HKED AGVI CSEF MSLR LTSE ASRE ACAG RLEV FYNG AWGT VGKS SMSE TTVG VVCR QLGC ADKG KINP ASLD KAMS IPMW VDNV QCPK GPDT LWQC PSSP WEKR LASP SEET WITC DNKI RLQE GPTS CSGR VEIW HGGS WGTV CDDS WDLD DAQV VCQQ LGCG PALK AFKE AEFG QGTG PIWL NEVK CKGN ESSL WDCP ARRW GHSE CGHK EDAA VNCT DISV QKTP QKAT TGRS SRQS S
Gene ID:9332
Uniprot:Q86VB7
Cellular Location:Cell membrane, Secreted, Single-pass type I membrane protein
Calculated MW:121kDa/124kDa/125kDa
Observed MW:160kDa
Synonyms:CD163, M130, MM130, SCARI1
Background:The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
NCBI Summary:The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
UniProt Code:Q86VB7
NCBI GenInfo Identifier:313104083
NCBI Gene ID:9332
NCBI Accession:
UniProt Related Accession:Q86VB7
Molecular Weight:
NCBI Full Name:Scavenger receptor cysteine-rich type 1 protein M130
NCBI Synonym Full Names:CD163 molecule
NCBI Official Symbol:CD163  
NCBI Official Synonym Symbols:M130; MM130; SCARI1  
NCBI Protein Information:scavenger receptor cysteine-rich type 1 protein M130
UniProt Protein Name:
Protein Family:Scavenger receptor cysteine-rich type 1 protein
UniProt Gene Name:
Anti-CD163 Polyclonal Antibody (CAB8383)Western blot analysis of extracts of various cell lines, using CD163 antibody (CAB8383) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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