Name: Anti-CD160 antigen Antibody (CAB8189)
Brand: Immunology Antibodies 3
SKU: CAB8189
Availability: OutOfStock

Antibody Name:	CD160 Rabbit Polyclonal Antibody
Antibody SKU:	CAB8189
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human CD160 (NP_008984.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	Jurkat, HT-29, U-937, Raji, Mouse spleen, Mouse small intestine, Mouse thymus, Rat thymus

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human CD160 (NP_008984.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MLLE PGRG CCAL AILL AIVD IQSG GCIN ITSS ASQE GTRL NLIC TVWH KKEE AEGF VVFL CKDR SGDC SPET SLKQ LRLK RDPG IDGV GEIS SQLM FTIS QVTP LHSG TYQC CARS QKSG IRLQ GHFF SILF TETG NYTV TGLK QRQH LEFS HNEG TLSS GFLQ EKVW VMLV TSLV ALQA L
Gene ID:	11126
Uniprot:	O95971
Cellular Location:	Cell membrane, GPI-anchor, Lipid-anchor
Calculated MW:	19kDa
Observed MW:	20kDa

Synonyms:

CD160, BY55, NK1, NK28

Background:

CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.

UniProt Protein Function:	Receptor showing broad specificity for both classical and non-classical MHC class I molecules.
NCBI Summary:	CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]
UniProt Code:	O95971
NCBI GenInfo Identifier:	17372903
NCBI Gene ID:	11126
NCBI Accession:	O95971.1
UniProt Related Accession:	O95971
Molecular Weight:	19,810 Da
NCBI Full Name:	CD160 antigen
NCBI Synonym Full Names:	CD160 molecule
NCBI Official Symbol:	CD160
NCBI Official Synonym Symbols:	NK1; BY55; NK28
NCBI Protein Information:	CD160 antigen
UniProt Protein Name:	CD160 antigen
UniProt Synonym Protein Names:	Natural killer cell receptor BY55; CD_antigen: CD160
Protein Family:	CD160 antigen
UniProt Gene Name:	CD160

Anti-CD160 antigen Polyclonal Antibody (CAB8189)

Western blot analysis of extracts of various cell lines, using CD160 antibody (CAB8189) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

Antibodies

CD160 Antibody (PACO00548)

CD160 Antibody (PACO01987)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)