Anti-CD146/MCAM Antibody (CAB9703)
- SKU:
- CAB9703
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CD146
- Synonyms:
- MUC18
- Research Area:
- Cell Biology
Description
| Product Name: | CD146/MCAM Rabbit mAb |
| Product Code: | CAB9703 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CD146, MUC18 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CD146/MCAM |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A375, Mouse lung, Rat lung |
| Immunogen: | A synthesized peptide derived from human CD146/MCAM |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4162 |
| Uniprot: | P43121 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 72kDa |
| Observed MW: | 120kDa |
| UniProt Protein Function: | MCAM: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: extracellular space; focal adhesion; integral to membrane; plasma membrane; nucleus; external side of plasma membrane Biological Process: anatomical structure morphogenesis; glomerular filtration; angiogenesis; cell adhesion; positive regulation of cell migration |
| UniProt Code: | P43121 |
| NCBI GenInfo Identifier: | 85681878 |
| NCBI Gene ID: | 4162 |
| NCBI Accession: | P43121.2 |
| UniProt Secondary Accession: | P43121,O95812, Q59E86, Q6PHR3, Q6ZTR2, |
| UniProt Related Accession: | P43121 |
| Molecular Weight: | 646 |
| NCBI Full Name: | Cell surface glycoprotein MUC18 |
| NCBI Synonym Full Names: | melanoma cell adhesion molecule |
| NCBI Official Symbol: | MCAM |
| NCBI Official Synonym Symbols: | CD146; MUC18 |
| NCBI Protein Information: | cell surface glycoprotein MUC18; Gicerin; melanoma adhesion molecule; cell surface glycoprotein P1H12; melanoma-associated antigen A32; melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen |
| UniProt Protein Name: | Cell surface glycoprotein MUC18 |
| UniProt Synonym Protein Names: | Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD_antigen: CD146 |
| Protein Family: | Cell surface glycoprotein |
| UniProt Gene Name: | MCAM |
| UniProt Entry Name: | MUC18_HUMAN |
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