Immunology Antibodies 3

Anti-CD14 Antibody (CAB19011)

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SKU:
CAB19011
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-CD14 Antibody
Antibody SKU:CAB19011
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CD14
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:U-87MG, THP-1, A-549, RAW264.7
Immunogen:A synthesized peptide derived from human CD14
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:929
Uniprot:P08571
Cellular Location:Cell membrane, GPI-anchor, Lipid-anchor, Secreted
Calculated MW:53kDa
Observed MW:50-65kDa
Anti-CD14 Antibody (CAB19011)Western blot - CD14 Rabbit mAb (CAB19011)
Synonyms:CD14
Background:The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]
UniProt Protein Function:CD14: Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor

Cellular Component: anchored to external side of plasma membrane; extracellular space; cell surface; membrane; plasma membrane; lipopolysaccharide receptor complex; lipid raft; external side of plasma membrane

Molecular Function:lipopolysaccharide binding

Biological Process: response to bacterium; immune system process; response to molecule of bacterial origin; innate immune response; positive regulation of endocytosis; positive regulation of tumor necrosis factor production; inflammatory response; positive regulation of cytokine secretion

NCBI Summary:This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte/macrophage cells. This gene product acts as a co-receptor that binds several microbial and fungal molecules, including lipopolysaccharides (LPS). This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex. The product of this gene is found in two forms, either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor. [provided by RefSeq, Jul 2014]
UniProt Code:P08571
NCBI GenInfo Identifier:6753332
NCBI Gene ID:12475
NCBI Accession:NP_033971.1
UniProt Related Accession:P10810
Molecular Weight:
NCBI Full Name:monocyte differentiation antigen CD14
NCBI Synonym Full Names:CD14 antigen
NCBI Official Symbol:Cd14  
NCBI Protein Information:monocyte differentiation antigen CD14
UniProt Protein Name:Monocyte differentiation antigen CD14
UniProt Synonym Protein Names:Myeloid cell-specific leucine-rich glycoprotein; CD_antigen: CD14
Protein Family:Monocyte differentiation antigen
UniProt Gene Name:Cd14  
UniProt Entry Name:CD14_MOUSE
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