Cardiovascular Antibodies

Anti-CD13 Antibody (CAB11669)

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SKU:
CAB11669
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cardiovascular

Description

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Antibody Name:Anti-CD13 Antibody
Antibody SKU:CAB11669
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CD13
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:THP-1, Mouse kidney, Rat kidney
Immunogen:A synthesized peptide derived from human CD13
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:290
Uniprot:P15144
Cellular Location:Cell membrane, Cytoplasm, Single-pass type II membrane protein, cytosol
Calculated MW:110kDa
Observed MW:160KDa
Anti-CD13 AntibodyWestern blot - CD13 Rabbit mAb (CAB11669)
Synonyms:APN, CD13, GP150, LAP1, P150, PEPN
Background:Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
UniProt Protein Function:CD13: Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection. Belongs to the peptidase M1 family.
UniProt Protein Details:

Protein type:EC 3.4.11.2; Membrane protein, integral; Other Amino Acids Metabolism - glutathione; Protease; Receptor, misc.

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: ER-Golgi intermediate compartment; extracellular space; integral to plasma membrane; lysosomal membrane

Molecular Function:aminopeptidase activity; metallopeptidase activity; peptide binding; receptor activity; zinc ion binding

Biological Process: peptide catabolic process

NCBI Summary:Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
UniProt Code:P15144
NCBI GenInfo Identifier:143811362
NCBI Gene ID:290
NCBI Accession:P15144.4
UniProt Secondary Accession:P15144,Q16728, Q6GT90, Q8IUK3, Q8IVH3, Q9UCE0,
UniProt Related Accession:P15144
Molecular Weight:
NCBI Full Name:Aminopeptidase N
NCBI Synonym Full Names:alanyl aminopeptidase, membrane
NCBI Official Symbol:ANPEP  
NCBI Official Synonym Symbols:APN; CD13; LAP1; P150; PEPN; GP150  
NCBI Protein Information:aminopeptidase N
UniProt Protein Name:Aminopeptidase N
UniProt Synonym Protein Names:Alanyl aminopeptidase; Aminopeptidase M; AP-M; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; gp150; CD_antigen: CD13
UniProt Gene Name:ANPEP  
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