Cell Biology Antibodies 7
Anti-CD11A Antibody (CAB1644)
- SKU:
- CAB1644
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-CD11A Antibody |
Antibody SKU: | CAB1644 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-306 of human CD11A (NP_001107852.1). |
Application: | WB IHC IF |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | Jurkat, HepG2, Mouse liver |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-306 of human CD11A (NP_001107852.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | YNLD VRGA RSFS PPRA GRHF GYRV LQVG NGVI VGAP GEGN STGS LYQC QSGT GHCL PVTL RGSN YTSK YLGM TLAT DPTD GSIL FAAV QFST SYKT EFDF SDYV KRKD PDAL LKHV KHML LLTN TFGA INYV ATEV FREE LGAR PDAT KVLI IITD GEAT DSGN IDAA KDII RYII GIGK HFQT KESQ ETLH KFAS KPAS EFVK ILDT FEKL KDLF TELQ KKIY VIEG TSKQ DLTS FNME LSSS GISA DLSR GHAV VGAV GAKD WAGG FLDL KADL QDDT F |
Gene ID: | 3683 |
Uniprot: | P20701 |
Cellular Location: | Membrane, Single-pass type I membrane protein |
Calculated MW: | 119kDa/128kDa/134kDa |
Observed MW: | 175kDa |
Synonyms: | CD11A, LFA-1, LFA1A, CD11a, ITGAL |
Background: | ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | ITGAL: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Belongs to the integrin alpha chain family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion; Cell surface Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: cell surface; membrane; plasma membrane; immunological synapse; intercellular junction; integrin complex; external side of plasma membrane Molecular Function:protein binding; protein heterodimerization activity; metal ion binding; protein complex binding; ICAM-3 receptor activity; cell adhesion molecule binding Biological Process: integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; regulation of immune response; cell-matrix adhesion; activated T cell proliferation; positive regulation of calcium-mediated signaling; signal transduction; receptor clustering; heterophilic cell adhesion; leukocyte adhesion; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; positive regulation of T cell proliferation; inflammatory response; blood coagulation; cell adhesion; cell motility; leukocyte migration |
NCBI Summary: | ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P20701 |
NCBI GenInfo Identifier: | 88911345 |
NCBI Gene ID: | 3683 |
NCBI Accession: | P20701.3 |
UniProt Secondary Accession: | P20701,O43746, Q45H73, Q96HB1, Q9UBC8, |
UniProt Related Accession: | P20701 |
Molecular Weight: | |
NCBI Full Name: | Integrin alpha-L |
NCBI Synonym Full Names: | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) |
NCBI Official Symbol: | ITGAL |
NCBI Official Synonym Symbols: | CD11A; LFA-1; LFA1A |
NCBI Protein Information: | integrin alpha-L; LFA-1A; LFA-1 alpha; integrin gene promoter; CD11 antigen-like family member A; lymphocyte function-associated antigen 1; leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide |
UniProt Protein Name: | Integrin alpha-L |
UniProt Synonym Protein Names: | CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD_antigen: CD11a |
Protein Family: | Integrin |
UniProt Gene Name: | ITGAL |
UniProt Entry Name: | ITAL_HUMAN |