Cell Biology Antibodies 9

Anti-CCT8 Antibody (CAB4449)

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SKU:
CAB4449
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CCT8
Synonyms:
C21orf112
Synonyms:
Cctq
Synonyms:
D21S246
Synonyms:
PRED71
Research Area:
Cell Biology

Description

Product Name:CCT8 Rabbit pAb
Product Code:CAB4449
Size:20uL, 50uL, 100uL
Synonyms:CCT8, C21orf112, Cctq, D21S246, PRED71
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 248-497 of human CCT8 (NP_001269837.1).
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:1000 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:B cells, LO2, 293T, HeLa, Mouse brain, Mouse liver, Mouse lung, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 248-497 of human CCT8 (NP_001269837.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DMAL HYAN KYNI MLVR LNSK WDLR RLCK TVGA TALP RLTP PVLE EMGH CDSV YLSE VGDT QVVV FKHE KEDG AIST IVLR GSTD NLMD DIER AVDD GVNT FKVL TRDK RLVP GGGA TEIE LAKQ ITSY GETC PGLE QYAI KKFA EAFE AIPR ALAE NSGV KANE VISK LYAV HQEG NKNV GLDI EAEV PAVK DMLE AGIL DTYL GKYW AIKL ATNA AVTV LRVD QIIM AKPA GGPK PPSG KKDW DDDQ ND
Gene ID:10694
Uniprot:P50990
Cellular Location:Cytoplasm, centrosome, cilium basal body, cytoskeleton, microtubule organizing center
Calculated MW:51kDa/57kDa/59kDa
Observed MW:60kDa
UniProt Protein Function:CCT8: a chaperone of the TCP-1 chaperonin family. A part of a hetero-oligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Chaperone

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: centrosome; chaperonin-containing T-complex; cytoplasm; cytosol; intermediate filament cytoskeleton; microtubule; nucleoplasm

Molecular Function:ATPase activity, coupled; protein binding

Biological Process: positive regulation of telomere maintenance via telomerase; protein folding; protein stabilization

NCBI Summary:This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]
UniProt Code:P50990
NCBI GenInfo Identifier:9988062
NCBI Gene ID:10694
NCBI Accession:P50990.4
UniProt Secondary Accession:P50990,Q4VBP8, A6NN54, B4DEM7, B4DQH4,
UniProt Related Accession:P50990
Molecular Weight:51,586 Da
NCBI Full Name:T-complex protein 1 subunit theta
NCBI Synonym Full Names:chaperonin containing TCP1 subunit 8
NCBI Official Symbol:CCT8  
NCBI Official Synonym Symbols:Cctq; PRED71; D21S246; C21orf112  
NCBI Protein Information:T-complex protein 1 subunit theta
UniProt Protein Name:T-complex protein 1 subunit theta
UniProt Synonym Protein Names:CCT-theta; Renal carcinoma antigen NY-REN-15
Protein Family:Probable T-complex protein
UniProt Gene Name:CCT8  
UniProt Entry Name:TCPQ_HUMAN
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