Immunology Antibodies 3

Anti-CCR9 Antibody (CAB17087)

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SKU:
CAB17087
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-CCR9 Antibody
Antibody SKU:CAB17087
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human CCR9.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:
Immunogen:A synthetic peptide of human CCR9.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10803
Uniprot:P51686
Cellular Location:
Calculated MW:40kDa/42kDa
Observed MW:Refer to figures
Synonyms:CCR9, CC-CKR-9, CDw199, GPR-9-6, GPR28
Background:The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:CCR9: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function:C-C chemokine receptor activity; chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cellular defense response; immune response; chemotaxis

NCBI Summary:The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Code:P51686
NCBI GenInfo Identifier:114152781
NCBI Gene ID:10803
NCBI Accession:P51686.2
UniProt Secondary Accession:P51686,Q9WUT7,
UniProt Related Accession:P51686
Molecular Weight:40,713 Da
NCBI Full Name:C-C chemokine receptor type 9
NCBI Synonym Full Names:chemokine (C-C motif) receptor 9
NCBI Official Symbol:CCR9  
NCBI Official Synonym Symbols:GPR28; CDw199; GPR-9-6; CC-CKR-9  
NCBI Protein Information:C-C chemokine receptor type 9; G protein-coupled receptor 28
UniProt Protein Name:C-C chemokine receptor type 9
UniProt Synonym Protein Names:G-protein coupled receptor 28; GPR-9-6; CD_antigen: CDw199
Protein Family:C-C chemokine receptor
UniProt Gene Name:CCR9  
UniProt Entry Name:CCR9_HUMAN
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