Anti-CCR3 Antibody (CAB20253)

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SKU:
CAB20253
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CCR3
Synonyms:
CC-CKR-3
Synonyms:
CD193
Synonyms:
CKR3
Synonyms:
CMKBR3

Description

Product Name:CCR3 Rabbit pAb
Product Code:CAB20253
Size:50uL, 100uL
Synonyms:CCR3, CC-CKR-3, CD193, CKR3, CMKBR3
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human CCR3
Applications:WB, IHC
Recommended Dilutions:WB 1:200 - 1:1000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, A-549, Raji, Mouse liver, Rat spleen
Immunogen:A synthetic peptide of human CCR3
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1232
Uniprot:P51677
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:41kDa/43kDa
Observed MW:50KDa
UniProt Protein Function:CCR3: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:GPCR, family 1; Receptor, cytokine; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:chemokine receptor activity; protein binding

Biological Process: cell adhesion; cellular defense response; elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to cAMP nucleotide second messenger; positive regulation of angiogenesis

NCBI Summary:The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
UniProt Code:P51677
NCBI GenInfo Identifier:1705892
NCBI Gene ID:1232
NCBI Accession:P51677.1
UniProt Secondary Accession:P51677,Q15748, Q2YDB9, Q86WD2, Q8TDP6, Q9ULY8, B3KVQ1 F5GWL6,
UniProt Related Accession:P51677
Molecular Weight:43,453 Da
NCBI Full Name:C-C chemokine receptor type 3
NCBI Synonym Full Names:C-C motif chemokine receptor 3
NCBI Official Symbol:CCR3  
NCBI Official Synonym Symbols:CKR3; CD193; CMKBR3; CC-CKR-3  
NCBI Protein Information:C-C chemokine receptor type 3
UniProt Protein Name:C-C chemokine receptor type 3
UniProt Synonym Protein Names:Eosinophil eotaxin receptor; CD_antigen: CD193
Protein Family:C-C chemokine receptor
UniProt Gene Name:CCR3  
UniProt Entry Name:CCR3_HUMAN
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