Name: Anti-CCR1 Antibody (CAB18341)
Brand: Cell Biology Antibodies 18
SKU: CAB18341
Availability: OutOfStock

Antibody Name:	Anti-CCR1 Antibody
Antibody SKU:	CAB18341
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC IF
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthetic peptide of human CCR1.

Application:	WB IHC IF
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:	Mouse, Rat
Positive Samples:	Mouse lung

Immunogen:	A synthetic peptide of human CCR1.
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	1230
Uniprot:	P32246
Cellular Location:
Calculated MW:
Observed MW:	41kDa

Western blot - CCR1 Rabbit pAb (CAB18341)

Synonyms:	CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1, CCR1
Background:

UniProt Protein Function:	CCR1: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:	Protein type:Receptor, GPCR; Motility/polarity/chemotaxis; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 3p21 Cellular Component: external side of plasma membrane; integral to plasma membrane; plasma membrane Molecular Function:C-C chemokine binding; C-C chemokine receptor activity; chemokine receptor activity; phosphoinositide phospholipase C activity; protein binding Biological Process: calcium ion transport; cell adhesion; cell surface receptor linked signal transduction; cell-cell signaling; cellular calcium ion homeostasis; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; exocytosis; G-protein signaling, coupled to cyclic nucleotide second messenger; immune response; negative regulation of bone mineralization; positive regulation of calcium ion transport; positive regulation of cell migration; positive regulation of osteoclast differentiation; response to wounding
NCBI Summary:	This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]
UniProt Code:	P32246
NCBI GenInfo Identifier:	416802
NCBI Gene ID:	1230
NCBI Accession:	P32246.1
UniProt Secondary Accession:	P32246,Q86VA9,
UniProt Related Accession:	P32246
Molecular Weight:	41,173 Da
NCBI Full Name:	C-C chemokine receptor type 1
NCBI Synonym Full Names:	C-C motif chemokine receptor 1
NCBI Official Symbol:	CCR1
NCBI Official Synonym Symbols:	CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1
NCBI Protein Information:	C-C chemokine receptor type 1
UniProt Protein Name:	C-C chemokine receptor type 1
UniProt Synonym Protein Names:	HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CD_antigen: CD191
Protein Family:	C-C chemokine receptor
UniProt Gene Name:	CCR1
UniProt Entry Name:	CCR1_HUMAN