Cell Biology Antibodies 6

Anti-CCL7 Antibody (CAB16221)

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SKU:
CAB16221
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CCL7 Antibody
Antibody SKU:CAB16221
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-99 of human CCL7 (NP_006264.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-99 of human CCL7 (NP_006264.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKAS AALL CLLL TAAA FSPQ GLAQ PVGI NTST TCCY RFIN KKIP KQRL ESYR RTTS SHCP REAV IFKT KLDK EICA DPTQ KWVQ DFMK HLDK KTQT PKL
Gene ID:6354
Uniprot:P80098
Cellular Location:
Calculated MW:11kDa
Observed MW:Refer to figures
Synonyms:CCL7, FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7
Background:This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q.
UniProt Protein Function:CCL7: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:

Protein type:Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q11.2-q12

Cellular Component: extracellular space; extracellular region

Molecular Function:heparin binding; CCR1 chemokine receptor binding; CCR2 chemokine receptor binding; chemokine activity

Biological Process: cellular calcium ion homeostasis; regulation of cell shape; monocyte chemotaxis; cell-cell signaling; eosinophil chemotaxis; response to gamma radiation; cytoskeleton organization and biogenesis; immune response; chemotaxis; inflammatory response; signal transduction; positive regulation of cell migration

NCBI Summary:This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]
UniProt Code:P80098
NCBI GenInfo Identifier:1170890
NCBI Gene ID:6354
NCBI Accession:P80098.3
UniProt Secondary Accession:P80098,Q569J6,
UniProt Related Accession:P80098
Molecular Weight:11,200 Da
NCBI Full Name:C-C motif chemokine 7
NCBI Synonym Full Names:chemokine (C-C motif) ligand 7
NCBI Official Symbol:CCL7  
NCBI Official Synonym Symbols:FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7  
NCBI Protein Information:C-C motif chemokine 7; small-inducible cytokine A7; monocyte chemotactic protein 3; monocyte chemoattractant protein 3; small inducible cytokine A7 (monocyte chemotactic protein 3)
UniProt Protein Name:C-C motif chemokine 7
UniProt Synonym Protein Names:Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; MCP-3; NC28; Small-inducible cytokine A7
Protein Family:C-C motif chemokine
UniProt Gene Name:CCL7  
UniProt Entry Name:CCL7_HUMAN
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