Cell Biology Antibodies 7
Anti-CCL4 Antibody (CAB1671)
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- SKU:
- CAB1671
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CCL4 Antibody |
| Antibody SKU: | CAB1671 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 30 to the C-terminus of human CCL4 (NP_002975.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | SGC-7901 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 30 to the C-terminus of human CCL4 (NP_002975.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PPTA CCFS YTAR KLPR NFVV DYYE TSSL CSQP AVVF QTKR SKQV CADP SESW VQEY VYDL ELN |
| Gene ID: | 6351 |
| Uniprot: | P13236 |
| Cellular Location: | Secreted |
| Calculated MW: | 10kDa |
| Observed MW: | 10kDa |
| Synonyms: | CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 |
| Background: | The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. |
| UniProt Protein Function: | CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine Chromosomal Location of Human Ortholog: 17q12 Cellular Component: extracellular space; extracellular region Molecular Function:identical protein binding; protein binding; CCR1 chemokine receptor binding; chemokine activity; cytokine activity; CCR5 chemokine receptor binding Biological Process: cell-cell signaling; response to toxin; response to virus; establishment and/or maintenance of cell polarity; positive regulation of calcium-mediated signaling; immune response; positive regulation of calcium ion transport; inflammatory response; cell motility; signal transduction; cell adhesion |
| NCBI Summary: | The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012] |
| UniProt Code: | P13236 |
| NCBI GenInfo Identifier: | 127080 |
| NCBI Gene ID: | 6351 |
| NCBI Accession: | P13236.1 |
| UniProt Secondary Accession: | P13236,P22617, Q13704, Q3SXL8, Q6FGI8, |
| UniProt Related Accession: | P13236 |
| Molecular Weight: | 92 |
| NCBI Full Name: | C-C motif chemokine 4 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 4 |
| NCBI Official Symbol: | CCL4 |
| NCBI Official Synonym Symbols: | ACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta |
| NCBI Protein Information: | C-C motif chemokine 4; PAT 744; SIS-gamma; MIP-1-beta(1-69); secreted protein G-26; T-cell activation protein 2; G-26 T-lymphocyte-secreted protein; lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; small inducible cytokine A4 |
| UniProt Protein Name: | C-C motif chemokine 4 |
| UniProt Synonym Protein Names: | G-26 T-lymphocyte-secreted protein; HC21; Lymphocyte activation gene 1 protein; LAG-1; MIP-1-beta(1-69); Macrophage inflammatory protein 1-beta; MIP-1-beta; PAT 744; Protein H400; SIS-gamma; Small-inducible cytokine A4; T-cell activation protein 2; ACT-2 |
| Protein Family: | C-C motif chemokine |
| UniProt Gene Name: | CCL4 |
| UniProt Entry Name: | CCL4_HUMAN |
 | Western blot analysis of extracts of SGC-7901 cells, using CCL4 antibody (CAB1671). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human colon using CCL4 antibody (CAB1671) at dilution of 1:100 (40x lens). |
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