Cell Biology Antibodies 8
Anti-CCL3L1 Antibody (CAB2852)
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- SKU:
- CAB2852
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CCL3L1 Antibody |
| Antibody SKU: | CAB2852 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-93 of human CCL3L1 (NP_066286.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | B cells |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-93 of human CCL3L1 (NP_066286.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | APLA ADTP TACC FSYT SRQI PQNF IADY FETS SQCS KPSV IFLT KRGR QVCA DPSE EWVQ KYVS DLEL SA |
| Gene ID: | 6349 |
| Uniprot: | P16619 |
| Cellular Location: | Secreted |
| Calculated MW: | 10kDa |
| Observed MW: | 12kDa |
| Synonyms: | CCL3L1, 464.2, D17S1718, G0S19-2, LD78, LD78-beta(1-70), LD78BETA, MIP1AP, SCYA3L, SCYA3L1 |
| Background: | This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | CCL3L1: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1- infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Belongs to the intercrine beta (chemokine CC) family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine Chromosomal Location of Human Ortholog: 17q21.1 Cellular Component: extracellular space; extracellular region Molecular Function:chemokine activity Biological Process: negative regulation of cell proliferation; immune response; inflammatory response Disease: Human Immunodeficiency Virus Type 1, Susceptibility To |
| NCBI Summary: | This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014] |
| UniProt Code: | P16619 |
| NCBI GenInfo Identifier: | 127077 |
| NCBI Gene ID: | 414062 |
| NCBI Accession: | P16619.1 |
| UniProt Secondary Accession: | P16619,Q3B7A8, Q53YA5, Q96I68, A6NGK6, B2RUX4, |
| UniProt Related Accession: | P16619 |
| Molecular Weight: | 93 |
| NCBI Full Name: | C-C motif chemokine 3-like 1 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 3-like 3 |
| NCBI Official Symbol: | CCL3L3 |
| NCBI Official Synonym Symbols: | LD78; 464.2; SCYA3L; G0S19-2; SCYA3L1; D17S1718; LD78BETA |
| NCBI Protein Information: | C-C motif chemokine 3-like 1; LD78-beta(1-70); small inducible cytokine A3-like 1; G0/G1 switch regulatory protein 19-2; tonsillar lymphocyte LD78 beta protein; chemokine (C-C motif) ligand 3-like, centromeric |
| UniProt Protein Name: | C-C motif chemokine 3-like 1 |
| UniProt Synonym Protein Names: | G0/G1 switch regulatory protein 19-2; LD78-beta(1-70); PAT 464.2; Small-inducible cytokine A3-like 1; Tonsillar lymphocyte LD78 beta proteinCleaved into the following 2 chains:LD78-beta(3-70); LD78-beta(5-70) |
| Protein Family: | C-C motif chemokine |
| UniProt Gene Name: | CCL3L1 |
| UniProt Entry Name: | CL3L1_HUMAN |
 | Western blot analysis of extracts of B-cell cells, using CCL3L1 antibody (CAB2852) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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