Cell Biology Antibodies 12

Anti-CCL27 Antibody (CAB9864)

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SKU:
CAB9864
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CCL27 Antibody
Antibody SKU:CAB9864
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-112 of human CCL27 (NP_006655.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:SKOV3, SW620, Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-112 of human CCL27 (NP_006655.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FLLP PSTA CCTQ LYRK PLSD KLLR KVIQ VELQ EADG DCHL QAFV LHLA QRSI CIHP QNPS LSQW FEHQ ERKL HGTL PKLN FGML RKMG
Gene ID:10850
Uniprot:Q9Y4X3
Cellular Location:Secreted
Calculated MW:12kDa
Observed MW:16kDa
Synonyms:CCL27, ALP, CTACK, CTAK, ESKINE, ILC, PESKY, SCYA27
Background:This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation.
UniProt Protein Function:CCL27: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. May play a role in cell migration during embryogenesis. Nuclear forms may facilitate cellular migration by inducing cytoskeletal relaxation. Binds to CCR10. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function:chemokine activity

Biological Process: cell-cell signaling; immune response; chemotaxis

NCBI Summary:This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]
UniProt Code:Q9Y4X3
NCBI GenInfo Identifier:7674366
NCBI Gene ID:10850
NCBI Accession:Q9Y4X3.1
UniProt Related Accession:Q9Y4X3
Molecular Weight:12,618 Da
NCBI Full Name:C-C motif chemokine 27
NCBI Synonym Full Names:chemokine (C-C motif) ligand 27
NCBI Official Symbol:CCL27  
NCBI Official Synonym Symbols:ALP; ILC; CTAK; CTACK; PESKY; ESKINE; SCYA27  
NCBI Protein Information:C-C motif chemokine 27; skinkine; CC chemokine ILC; IL-11 Ralpha-locus chemokine; small-inducible cytokine A27; IL-11 R-alpha-locus chemokine; cutaneous T-cell attracting chemokine; cutaneous T-cell-attracting chemokine; small inducible cytokine subfamily A (Cys-Cys), member 27
UniProt Protein Name:C-C motif chemokine 27
UniProt Synonym Protein Names:CC chemokine ILC; Cutaneous T-cell-attracting chemokine; CTACK; ESkine; IL-11 R-alpha-locus chemokine; Skinkine; Small-inducible cytokine A27
Protein Family:C-C motif chemokine
UniProt Gene Name:CCL27  
UniProt Entry Name:CCL27_HUMAN
Anti-CCL27 Polyclonal Antibody (CAB9864)Western blot analysis of extracts of various cell lines, using CCL27 antibody (CAB9864) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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