Cell Biology Antibodies 8
Anti-CCL25 Antibody (CAB2685)
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- SKU:
- CAB2685
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CCL25 Antibody |
| Antibody SKU: | CAB2685 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-150 of human CCL25 (NP_005615.2). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-150 of human CCL25 (NP_005615.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QGVF EDCC LAYH YPIG WAVL RRAW TYRI QEVS GSCN LPAA IFYL PKRH RKVC GNPK SREV QRAM KLLD ARNK VFAK LHHN TQTF QAGP HAVK KLSS GNSK LSSS KFSN PISS SKRN VSLL ISAN SGL |
| Gene ID: | 6370 |
| Uniprot: | O15444 |
| Cellular Location: | Secreted |
| Calculated MW: | 9kDa/16kDa |
| Observed MW: |
| Synonyms: | CCL25, Ckb15, SCYA25, TECK |
| Background: | This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CCL25: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Belongs to the intercrine beta (chemokine CC) family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Chemokine; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: extracellular space; extracellular region Molecular Function:chemokine activity; chemokine receptor binding; CCR10 chemokine receptor binding; hormone activity Biological Process: G-protein coupled receptor protein signaling pathway; cell surface receptor linked signal transduction; immune response; inflammatory response; chemotaxis; positive regulation of cell-matrix adhesion; leukocyte migration |
| NCBI Summary: | This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014] |
| UniProt Code: | O15444 |
| NCBI GenInfo Identifier: | 212286066 |
| NCBI Gene ID: | 6370 |
| NCBI Accession: | O15444.2 |
| UniProt Secondary Accession: | O15444,Q96KJ7, A1L4J4, A6NI52, A8K9E7, B5MCA5, |
| UniProt Related Accession: | O15444 |
| Molecular Weight: | 16,538 Da |
| NCBI Full Name: | C-C motif chemokine 25 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 25 |
| NCBI Official Symbol: | CCL25 |
| NCBI Official Synonym Symbols: | TECK; Ckb15; SCYA25 |
| NCBI Protein Information: | C-C motif chemokine 25; TECKvar; Ck beta-15; chemokine TECK; thymus expressed chemokine; thymus-expressed chemokine; small-inducible cytokine A25; small inducible cytokine subfamily A (Cys-Cys), member 25 |
| UniProt Protein Name: | C-C motif chemokine 25 |
| UniProt Synonym Protein Names: | Chemokine TECK; Small-inducible cytokine A25; Thymus-expressed chemokine |
| UniProt Gene Name: | CCL25 |
| UniProt Entry Name: | CCL25_HUMAN |
 | Immunofluorescence analysis of MCF7 cells using CCL25 antibody (CAB2685). Blue: DAPI for nuclear staining. |
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