Cell Biology Antibodies 8
Anti-CCL24 Antibody (CAB2684)
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- SKU:
- CAB2684
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CCL24 Antibody |
| Antibody SKU: | CAB2684 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-119 of human CCL24 (NP_002982.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse spleen, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-119 of human CCL24 (NP_002982.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KRIP ENRV VSYQ LSSR STCL KAGV IFTT KKGQ QFCG DPKQ EWVQ RYMK NLDA KQKK ASPR ARAV AVKG PVQR YPGN QTTC |
| Gene ID: | 6369 |
| Uniprot: | O00175 |
| Cellular Location: | Secreted |
| Calculated MW: | 13kDa |
| Observed MW: | 13kDa |
| Synonyms: | CCL24, Ckb-6, MPIF-2, MPIF2, SCYA24 |
| Background: | This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. |
| UniProt Protein Function: | CCL24: Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family. |
| UniProt Protein Details: | Protein type:Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: extracellular space Molecular Function:chemokine activity Biological Process: cytoskeleton organization and biogenesis; chemotaxis; signal transduction; regulation of cell shape; positive regulation of angiogenesis; positive regulation of actin filament polymerization; cell-cell signaling; eosinophil chemotaxis; immune response; positive regulation of endothelial cell proliferation; inflammatory response; positive regulation of inflammatory response; positive regulation of cell migration |
| NCBI Summary: | This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00175 |
| NCBI GenInfo Identifier: | 6920081 |
| NCBI Gene ID: | 6369 |
| NCBI Accession: | O00175.2 |
| UniProt Related Accession: | O00175 |
| Molecular Weight: | |
| NCBI Full Name: | C-C motif chemokine 24 |
| NCBI Synonym Full Names: | C-C motif chemokine ligand 24 |
| NCBI Official Symbol: | CCL24 |
| NCBI Official Synonym Symbols: | Ckb-6; MPIF2; MPIF-2; SCYA24 |
| NCBI Protein Information: | C-C motif chemokine 24 |
| UniProt Protein Name: | C-C motif chemokine 24 |
| UniProt Synonym Protein Names: | CK-beta-6; Eosinophil chemotactic protein 2; Eotaxin-2; Myeloid progenitor inhibitory factor 2; MPIF-2; Small-inducible cytokine A24 |
| Protein Family: | C-C motif chemokine |
| UniProt Gene Name: | CCL24 |
| UniProt Entry Name: | CCL24_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CCL24 antibody (CAB2684) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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