Cell Biology Antibodies 5

Anti-CCL16 Antibody (CAB15317)

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SKU:
CAB15317
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CCL16 Antibody
Antibody SKU:CAB15317
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human CCL16 (NP_004581.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Rat
Positive Samples:Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human CCL16 (NP_004581.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKVS EAAL SLLV LILI ITSA SRSQ PKVP EWVN TPST CCLK YYEK VLPR RLVV GYRK ALNC HLPA IIFV TKRN REVC TNPN DDWV QEYI KDPN LPLL PTRN LSTV KIIT AKNG QPQL LNSQ
Gene ID:6360
Uniprot:O15467
Cellular Location:Secreted
Calculated MW:13kDa
Observed MW:14kDa
Synonyms:CCL16, CKb12, HCC-4, ILINCK, LCC-1, LEC, LMC, Mtn-1, NCC-4, NCC4, SCYA16, SCYL4
Background:This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10.
UniProt Protein Function:CCL16: Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:

Protein type:Chemokine; Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space; extracellular region

Molecular Function:chemokine activity; chemoattractant activity

Biological Process: cell-cell signaling; positive chemotaxis; cell communication; immune response; inflammatory response; chemotaxis

NCBI Summary:This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]
UniProt Code:O15467
NCBI GenInfo Identifier:6094382
NCBI Gene ID:6360
NCBI Accession:O15467.1
UniProt Secondary Accession:O15467,Q4KKU0,
UniProt Related Accession:O15467
Molecular Weight:13,600 Da
NCBI Full Name:C-C motif chemokine 16
NCBI Synonym Full Names:chemokine (C-C motif) ligand 16
NCBI Official Symbol:CCL16  
NCBI Official Synonym Symbols:LEC; LMC; NCC4; CKb12; HCC-4; LCC-1; Mtn-1; NCC-4; SCYL4; ILINCK; SCYA16  
NCBI Protein Information:C-C motif chemokine 16; monotactin-1; chemokine LEC; chemokine CC-4; new CC chemokine 4; liver CC chemokine-1; IL-10-inducible chemokine; liver-expressed chemokine; small-inducible cytokine A16; lymphocyte and monocyte chemoattractant; small inducible cytokine subfamily A (Cys-Cys), member 16
UniProt Protein Name:C-C motif chemokine 16
UniProt Synonym Protein Names:Chemokine CC-4; HCC-4; Chemokine LEC; IL-10-inducible chemokine; LCC-1; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; LMC; Monotactin-1; MTN-1; NCC-4; Small-inducible cytokine A16
Protein Family:Lectin-like protein
UniProt Gene Name:CCL16  
UniProt Entry Name:CCL16_HUMAN
Anti-CCL16 Antibody (CAB15317)Western blot analysis of extracts of Rat liver, using CCL16 antibody (CAB15317) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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