ChIP Antibodies
Anti-CCK Antibody (CAB1759)
- SKU:
- CAB1759
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CCK Antibody |
| Antibody SKU: | CAB1759 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-115 of human CCK (NP_000720.1). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-115 of human CCK (NP_000720.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QPVP PADP AGSG LQRA EEAP RRQL RVSQ RTDG ESRA HLGA LLAR YIQQ ARKA PSGR MSIV KNLQ NLDP SHRI SDRD YMGW MDFG RRSA EEYE YPS |
| Gene ID: | 885 |
| Uniprot: | P06307 |
| Cellular Location: | Secreted |
| Calculated MW: | 12kDa |
| Observed MW: | Refer to figures |
| Synonyms: | CCK |
| Background: | This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CCK: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. Belongs to the gastrin/cholecystokinin family. |
| UniProt Protein Details: | Protein type:Secreted; Hormone; Secreted, signal peptide; Cell development/differentiation Chromosomal Location of Human Ortholog: 3p22.1 Cellular Component: axon; axon hillock; dendrite; extracellular region; extracellular space; perikaryon; terminal button Molecular Function:hormone activity; neuropeptide hormone activity; protein binding Biological Process: axonogenesis; behavioral fear response; caspase activation; eating behavior; negative regulation of appetite; neuron migration; positive regulation of cell proliferation; positive regulation of glutamate secretion; positive regulation of mitochondrial depolarization; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein oligomerization; protein kinase C activation; regulation of sensory perception of pain; release of cytochrome c from mitochondria; signal transduction |
| NCBI Summary: | This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015] |
| UniProt Code: | P06307 |
| NCBI GenInfo Identifier: | 115945 |
| NCBI Gene ID: | 885 |
| NCBI Accession: | P06307.1 |
| UniProt Related Accession: | P06307 |
| Molecular Weight: | 12,669 Da |
| NCBI Full Name: | Cholecystokinin |
| NCBI Synonym Full Names: | cholecystokinin |
| NCBI Official Symbol: | CCK |
| NCBI Protein Information: | cholecystokinin |
| UniProt Protein Name: | Cholecystokinin |
| UniProt Synonym Protein Names: | Cholecystokinin-58; CCK58 |
| UniProt Gene Name: | CCK |
| UniProt Entry Name: | CCKN_HUMAN |
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