Cell Biology Antibodies 6
Anti-CCDC6 Antibody (CAB16075)
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- SKU:
- CAB16075
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CCDC6 Antibody |
| Antibody SKU: | CAB16075 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 55-222 of human CCDC6 (NP_005427.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, HeLa, Jurkat, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 55-222 of human CCDC6 (NP_005427.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RLEE LTNR LASL QQEN KVLK IELE TYKL KCKA LQEE NRDL RKAS VTIQ ARAE QEEE FISN TLFK KIQA LQKE KETL AVNY EKEE EFLT NELS RKLM QLQH EKAE LEQH LEQE QEFQ VNKL MKKI KKLE NDTI SKQL TLEQ LRRE KIDL ENTL EQEQ EALV NRLW KRMD |
| Gene ID: | 8030 |
| Uniprot: | Q16204 |
| Cellular Location: | Cytoplasm, cytoskeleton |
| Calculated MW: | 53kDa |
| Observed MW: | 56kDa |
| Synonyms: | CCDC6, D10S170, H4, PTC, TPC, TST1 |
| Background: | This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma. |
| UniProt Protein Function: | CCDC6: Defects in CCDC6 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Oncoprotein; Apoptosis Chromosomal Location of Human Ortholog: 10q21 Cellular Component: cytoplasm Molecular Function:protein binding; structural constituent of cytoskeleton Disease: Thyroid Carcinoma, Papillary |
| NCBI Summary: | This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010] |
| UniProt Code: | Q16204 |
| NCBI GenInfo Identifier: | 292494979 |
| NCBI Gene ID: | 8030 |
| NCBI Accession: | Q16204.2 |
| UniProt Secondary Accession: | Q16204,Q15250, Q6GSG7, |
| UniProt Related Accession: | Q16204 |
| Molecular Weight: | 53,291 Da |
| NCBI Full Name: | Coiled-coil domain-containing protein 6 |
| NCBI Synonym Full Names: | coiled-coil domain containing 6 |
| NCBI Official Symbol: | CCDC6 |
| NCBI Official Synonym Symbols: | H4; PTC; TPC; TST1; D10S170 |
| NCBI Protein Information: | coiled-coil domain-containing protein 6 |
| UniProt Protein Name: | Coiled-coil domain-containing protein 6 |
| UniProt Synonym Protein Names: | Papillary thyroid carcinoma-encoded protein; Protein H4 |
| Protein Family: | Coiled-coil domain-containing protein |
| UniProt Gene Name: | CCDC6 |
| UniProt Entry Name: | CCDC6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CCDC6 antibody (CAB16075) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Immunohistochemistry of paraffin-embedded rat brain using CCDC6 antibody (CAB16075) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver cancer using CCDC6 antibody (CAB16075) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using CCDC6 antibody (CAB16075) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of L929 cells using CCDC6 antibody (CAB16075) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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