Cell Biology Antibodies 13
Anti-CBX7 Antibody (CAB17115)
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- SKU:
- CAB17115
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CBX7 Antibody |
| Antibody SKU: | CAB17115 |
| Antibody Size: | 20uL, 50 uL |
| Application: | IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human CBX7 (NP_783640.1). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human CBX7 (NP_783640.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MELS AIGE QVFA VESI RKKR VRKG KVEY LVKW KGWP PKYS TWEP EEHI LDPR LVMA YEEK EERD RASG YRKR GPKP KRLL LQRL YSMD LRSS HKAK GKEK LCFS LTCP LG |
| Gene ID: | 23492 |
| Uniprot: | O95931 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | CBX7 |
| Background: | This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. |
| UniProt Protein Function: | CBX7: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. |
| UniProt Protein Details: | Protein type:Transcription regulation Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus; PcG protein complex Molecular Function:protein binding Biological Process: negative regulation of transcription from RNA polymerase II promoter |
| UniProt Code: | O95931 |
| NCBI GenInfo Identifier: | 17433290 |
| NCBI Gene ID: | 23492 |
| NCBI Accession: | O95931.1 |
| UniProt Secondary Accession: | O95931,Q86T17, |
| UniProt Related Accession: | O95931 |
| Molecular Weight: | 28,341 Da |
| NCBI Full Name: | Chromobox protein homolog 7 |
| NCBI Synonym Full Names: | chromobox 7 |
| NCBI Official Symbol: | CBX7 |
| NCBI Protein Information: | chromobox protein homolog 7 |
| UniProt Protein Name: | Chromobox protein homolog 7 |
| Protein Family: | Chromobox protein |
| UniProt Gene Name: | CBX7 |
| UniProt Entry Name: | CBX7_HUMAN |
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