Cell Biology Antibodies 11
Anti-CBR3 Antibody (CAB7545)
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- SKU:
- CAB7545
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CBR3 Antibody |
| Antibody SKU: | CAB7545 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 118-277 of human CBR3 (NP_001227.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, NCI-H460, MCF7, BT-474, Mouse lung, Mouse brain, Mouse ovary, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 118-277 of human CBR3 (NP_001227.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TRNM CNEL LPIM KPHG RVVN ISSL QCLR AFEN CSED LQER FHSE TLTE GDLV DLMK KFVE DTKN EVHE REGW PNSP YGVS KLGV TVLS RILA RRLD EKRK ADRI LVNA CCPG PVKT DMDG KDSI RTVE EGAE TPVY LALL PPDA TEPQ GQLV HDKV VQNW |
| Gene ID: | 874 |
| Uniprot: | O75828 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 30kDa |
| Observed MW: | 31kDa |
| Synonyms: | CBR3, HEL-S-25, SDR21C2, hCBR3 |
| Background: | Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. |
| UniProt Protein Function: | CBR3: Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro). Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.1.1.184 Chromosomal Location of Human Ortholog: 21q22.2 Cellular Component: cytoplasm; cytosol; extracellular space; nucleoplasm Molecular Function:3-keto sterol reductase activity; carbonyl reductase (NADPH) activity Biological Process: cognition; phylloquinone catabolic process |
| NCBI Summary: | Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75828 |
| NCBI GenInfo Identifier: | 6014959 |
| NCBI Gene ID: | 874 |
| NCBI Accession: | O75828.3 |
| UniProt Secondary Accession: | O75828,Q6FHP2, |
| UniProt Related Accession: | O75828 |
| Molecular Weight: | 30,850 Da |
| NCBI Full Name: | Carbonyl reductase |
| NCBI Synonym Full Names: | carbonyl reductase 3 |
| NCBI Official Symbol: | CBR3 |
| NCBI Official Synonym Symbols: | hCBR3; SDR21C2; HEL-S-25 |
| NCBI Protein Information: | carbonyl reductase [NADPH] 3 |
| UniProt Protein Name: | Carbonyl reductase [NADPH] 3 |
| UniProt Synonym Protein Names: | NADPH-dependent carbonyl reductase 3; Short chain dehydrogenase/reductase family 21C member 2 |
| Protein Family: | Carbonyl reductase |
| UniProt Gene Name: | CBR3 |
| UniProt Entry Name: | CBR3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CBR3 antibody (CAB7545) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat brain using CBR3 antibody (CAB7545) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse stomach using CBR3 antibody (CAB7545) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of A549 cells using CBR3 antibody (CAB7545). Blue: DAPI for nuclear staining. |
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