Signal Transduction Antibodies 2

Anti-CBLL1 Antibody (CAB14932)

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SKU:
CAB14932
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-CBLL1 Antibody
Antibody SKU:CAB14932
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human CBLL1 (NP_079090.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse heart, Mouse brain, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human CBLL1 (NP_079090.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDHT DNEL QGTN SSGS LGGL DVRR RIPI KLIS KQAN KAKP APRT QRTI NRMP AKAP PGDE EGFD YNEE ERYD CKGG ELFA NQRR FPGH LFWD FQIN ILGE KDDT PVHF CDKC GLPI KIYG RMIP CKHV FCYD CAIL HEKK GDKM CPGC SDPV QRIE QCTR GSLF MCSI VQGC KRTY LSQR DLQA HINH RHMR AGKP VTRA SLEN VHPP IAPP PTEI PERF IMPP DKHH MSHI PPKQ HIMM
Gene ID:79872
Uniprot:Q75N03
Cellular Location:Nucleus, Nucleus speckle, nucleoplasm
Calculated MW:54kDa
Observed MW:60kDa
Synonyms:CBLL1, HAKAI, RNF188
Background:This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant.
UniProt Protein Function:CBLL1: Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation.
UniProt Protein Details:

Protein type:EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; EC 6.3.2.-; Cell adhesion; C2H2-type zinc finger protein; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 7q22.3

Cellular Component: ubiquitin ligase complex

Molecular Function:identical protein binding; protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: cell-cell adhesion; protein ubiquitination; positive regulation of endocytosis; negative regulation of cell adhesion; positive regulation of cell migration

NCBI Summary:This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]
UniProt Code:Q75N03
NCBI GenInfo Identifier:74762414
NCBI Gene ID:79872
NCBI Accession:Q75N03.1
UniProt Secondary Accession:Q75N03,Q9JIY2,
UniProt Related Accession:Q75N03
Molecular Weight:491
NCBI Full Name:E3 ubiquitin-protein ligase Hakai
NCBI Synonym Full Names:Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
NCBI Official Symbol:CBLL1  
NCBI Official Synonym Symbols:HAKAI; RNF188  
NCBI Protein Information:E3 ubiquitin-protein ligase Hakai; c-Cbl-like protein 1; RING finger protein 188; E-cadherin binding protein E7; Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1; casitas B-lineage lymphoma-transforming sequence-like protein 1; Cas-Br-M (murine) eco
UniProt Protein Name:E3 ubiquitin-protein ligase Hakai
UniProt Synonym Protein Names:Casitas B-lineage lymphoma-transforming sequence-like protein 1; RING finger protein 188; c-Cbl-like protein 1
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:CBLL1  
UniProt Entry Name:HAKAI_HUMAN
Anti-CBLL1 Antibody (CAB14932)Western blot analysis of extracts of various cell lines, using CBLL1 antibody (CAB14932) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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