Cell Biology Antibodies 7

Anti-CASQ2 Antibody (CAB16797)

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SKU:
CAB16797
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CASQ2 Antibody
Antibody SKU:CAB16797
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-399 of human CASQ2 (NP_001223.2).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Mouse, Rat
Positive Samples:Mouse heart, Rat heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-399 of human CASQ2 (NP_001223.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EEGL NFPT YDGK DRVV SLSE KNFK QVLK KYDL LCLY YHEP VSSD KVTQ KQFQ LKEI VLEL VAQV LEHK AIGF VMVD AKKE AKLA KKLG FDEE GSLY ILKG DRTI EFDG EFAA DVLV EFLL DLIE DPVE IISS KLEV QAFE RIED YIKL IGFF KSED SEYY KAFE EAAE HFQP YIKF FATF DKGV AKKL SLKM NEVD FYEP FMDE PIAI PNKP YTEE ELVE FVKE HQRP TLRR LRPE EMFE TWED DLNG IHIV AFAE KSDP DGYE FLEI LKQV ARDN TDNP DLSI LWID PDDF PLLV AYWE KTFK IDLF RPQI GVVN VTDA DSVW MEIP DDDD LPTA EELE DWIE DVLS GKIN TEDD DEDD DDDD NSDE EDND DSDD DDDE
Gene ID:845
Uniprot:O14958
Cellular Location:
Calculated MW:38kDa/46kDa
Observed MW:46kDa
Synonyms:CASQ2, PDIB2
Background:The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
UniProt Protein Function:calsequestrin 2: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions. Defects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2); also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Belongs to the calsequestrin family.
UniProt Protein Details:

Protein type:Calcium-binding

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: sarcoplasmic reticulum membrane; sarcoplasmic reticulum lumen; sarcoplasmic reticulum; junctional membrane complex; cytoplasm; voltage-gated calcium channel complex; intracellular; Z disc

Molecular Function:protein binding; protein homodimerization activity; calcium ion binding; calcium-dependent protein binding

Biological Process: protein polymerization; striated muscle contraction; regulation of heart rate; negative regulation of potassium ion transport; sequestering of calcium ion; detection of calcium ion; sarcomere organization; transmembrane transport; cardiac muscle contraction

Disease: Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy; Ventricular Tachycardia, Catecholaminergic Polymorphic, 2

NCBI Summary:The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq, Jul 2008]
UniProt Code:O14958
NCBI GenInfo Identifier:119395727
NCBI Gene ID:845
NCBI Accession:NP_001223.2
UniProt Secondary Accession:O14958,Q5T1D2, Q8TBW8, B2R7M6,
UniProt Related Accession:O14958
Molecular Weight:46,436 Da
NCBI Full Name:calsequestrin-2
NCBI Synonym Full Names:calsequestrin 2 (cardiac muscle)
NCBI Official Symbol:CASQ2  
NCBI Official Synonym Symbols:PDIB2  
NCBI Protein Information:calsequestrin-2; calsequestrin, cardiac muscle isoform; calsequestrin 2, fast-twitch, cardiac muscle
UniProt Protein Name:Calsequestrin-2
UniProt Synonym Protein Names:Calsequestrin, cardiac muscle isoform
Protein Family:Calsequestrin
UniProt Gene Name:CASQ2  
UniProt Entry Name:CASQ2_HUMAN
Anti-CASQ2 Antibody (CAB16797)Western blot analysis of extracts of various cell lines, using CASQ2 antibody (CAB16797) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-CASQ2 Antibody (CAB16797)Immunohistochemistry of paraffin-embedded mouse heart using CASQ2 antibody (CAB16797) at dilution of 1:100 (40x lens).
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