Cell Death Antibodies 1
Anti-Caspase-6 Antibody (CAB1784)
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- SKU:
- CAB1784
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-Caspase-6 Antibody |
| Antibody SKU: | CAB1784 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-293 of human Caspase-6 (NP_001217.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-293 of human Caspase-6 (NP_001217.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AFYK REMF DPAE KYKM DHRR RGIA LIFN HERF FWHL TLPE RRGT CADR DNLT RRFS DLGF EVKC FNDL KAEE LLLK IHEV STVS HADA DCFV CVFL SHGE GNHI YAYD AKIE IQTL TGLF KGDK CHSL VGKP KIFI IQAC RGNQ HDVP VIPL DVVD NQTE KLDT NITE VDAA SVYT LPAG ADFL MCYS VAEG YYSH RETV NGSW YIQD LCEM LGKY GSSL EFTE LLTL VNRK VSQR RVDF CKDP SAIG KKQV PCFA SMLT KKLH FFPK SN |
| Gene ID: | 839 |
| Uniprot: | P55212 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 22kDa/33kDa |
| Observed MW: | 35kDa |
| Synonyms: | CASP6, MCH2, caspase-6, Caspase-6 p18, Caspase-6 |
| Background: | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. |
| UniProt Protein Function: | CASP6: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Activation is suppressed by phosphorylation at Ser-257. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; Apoptosis; EC 3.4.22.59 Chromosomal Location of Human Ortholog: 4q25 Cellular Component: nucleoplasm; cytoplasm; cytosol Molecular Function:identical protein binding; protein binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity Biological Process: epithelial cell differentiation; apoptosis; proteolysis; cell structure disassembly during apoptosis |
| NCBI Summary: | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P55212 |
| NCBI GenInfo Identifier: | 26006981 |
| NCBI Gene ID: | 839 |
| NCBI Accession: | P55212.2 |
| UniProt Secondary Accession: | P55212,Q9BQE7, |
| UniProt Related Accession: | P55212 |
| Molecular Weight: | 33,310 Da |
| NCBI Full Name: | Caspase-6 |
| NCBI Synonym Full Names: | caspase 6, apoptosis-related cysteine peptidase |
| NCBI Official Symbol: | CASP6 |
| NCBI Official Synonym Symbols: | MCH2 |
| NCBI Protein Information: | caspase-6; apoptotic protease MCH-2; caspase 6, apoptosis-related cysteine protease |
| UniProt Protein Name: | Caspase-6 |
| UniProt Synonym Protein Names: | Apoptotic protease Mch-2 |
| Protein Family: | Caspase |
| UniProt Gene Name: | CASP6 |
| UniProt Entry Name: | CASP6_HUMAN |
 | Western blot analysis of extracts of mouse liver, using Caspase-6 Antibody (CAB1784) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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