Description
| Product Name: | CARS Rabbit mAb |
| Product Code: | CAB0438 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CARS, CARS1, CYSRS, MGC:11246, cysteinyl-tRNA synthetase |
| Applications: | WB, IHC |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CARS. |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | HeLa, A-549, MCF7, U-87MG, Rat pancreas |
| Immunogen: | A synthesized peptide derived from human CARS. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 833 |
| Uniprot: | P49589 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 75kDa |
| Observed MW: | 85KDa |
| UniProt Protein Function: | CARS: a class 1 aminoacyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. Two alternatively spliced isoforms are described. |
| UniProt Protein Details: | Protein type:EC 6.1.1.16; Oncoprotein; Translation; Ligase Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: cytoplasm; cytosol Molecular Function:protein binding; protein homodimerization activity; cysteine-tRNA ligase activity; metal ion binding; ATP binding; tRNA binding Biological Process: tRNA aminoacylation for protein translation; cysteinyl-tRNA aminoacylation; gene expression |
| NCBI Summary: | This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010] |
| UniProt Code: | P49589 |
| NCBI GenInfo Identifier: | 20141641 |
| NCBI Gene ID: | 833 |
| NCBI Accession: | P49589.3 |
| UniProt Secondary Accession: | P49589,Q53XI8, Q5HYE4, Q9HD24, Q9HD25, |
| UniProt Related Accession: | P49589 |
| Molecular Weight: | 748 |
| NCBI Full Name: | Cysteine--tRNA ligase, cytoplasmic |
| NCBI Synonym Full Names: | cysteinyl-tRNA synthetase |
| NCBI Official Symbol: | CARS |
| NCBI Official Synonym Symbols: | CARS1; CYSRS; MGC:11246 |
| NCBI Protein Information: | cysteine--tRNA ligase, cytoplasmic; cysteine translase; cysteine tRNA ligase 1, cytoplasmic |
| UniProt Protein Name: | Cysteine--tRNA ligase, cytoplasmic |
| UniProt Synonym Protein Names: | Cysteinyl-tRNA synthetase; CysRS |
| Protein Family: | CDP-archaeol synthase |
| UniProt Gene Name: | CARS |
| UniProt Entry Name: | SYCC_HUMAN |
