Anti-Cardiac Troponin C Antibody (CAB3816)

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SKU:
CAB3816
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CMD1Z
Synonyms:
CMH13
Synonyms:
TN-C
Synonyms:
TNC
Synonyms:
TNNC
Research Area:
Cell Biology

Description

Product Name:Cardiac Troponin C Rabbit mAb
Product Code:CAB3816
Size:20uL, 50uL, 100uL
Synonyms:CMD1Z, CMH13, TN-C, TNC, TNNC
Applications:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Cardiac Troponin C
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse heart, Rat heart
Immunogen:A synthesized peptide derived from human Cardiac Troponin C
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7134
Uniprot:P63316
Calculated MW:18kDa
Observed MW:18KDa
UniProt Protein Function:TNNC1: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13). A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Belongs to the troponin C family.
UniProt Protein Details:

Protein type:Calcium-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: nucleoplasm; troponin complex; mitochondrion; cytosol; actin cytoskeleton

Molecular Function:troponin T binding; actin filament binding; protein binding; protein homodimerization activity; troponin I binding; calcium ion binding; calcium-dependent protein binding

Biological Process: response to metal ion; regulation of ATPase activity; regulation of muscle contraction; diaphragm contraction; ventricular cardiac muscle morphogenesis; regulation of muscle filament sliding speed; cardiac muscle contraction; muscle filament sliding

Disease: Cardiomyopathy, Dilated, 1z; Cardiomyopathy, Familial Hypertrophic, 13

NCBI Summary:Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]
UniProt Code:P63316
NCBI GenInfo Identifier:54042075
NCBI Gene ID:7134
NCBI Accession:P63316.1
UniProt Related Accession:P63316
Molecular Weight:
NCBI Full Name:Troponin C, slow skeletal and cardiac muscles
NCBI Synonym Full Names:troponin C1, slow skeletal and cardiac type
NCBI Official Symbol:TNNC1  
NCBI Official Synonym Symbols:TNC; TN-C; TNNC; CMD1Z; CMH13  
NCBI Protein Information:troponin C, slow skeletal and cardiac muscles
UniProt Protein Name:Troponin C, slow skeletal and cardiac muscles
Protein Family:Tenascin
UniProt Gene Name:TNNC1  
UniProt Entry Name:TNNC1_HUMAN
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