Cell Biology Antibodies 15
Anti-CARD9 Antibody (CAB4920)
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- SKU:
- CAB4920
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CARD9
- Synonyms:
- CANDF2
- Synonyms:
- hCARD9
Description
| Product Name: | CARD9 Rabbit pAb |
| Product Code: | CAB4920 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CARD9, CANDF2, hCARD9 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 193-492 of human CARD9 (NP_434701.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 193-492 of human CARD9 (NP_434701.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SEEK GAAL MRNR DLQL EIDQ LKHS LMKA EDDC KVER KHTL KLRH AMEQ RPSQ ELLW ELQQ EKAL LQAR VQEL EASV QEGK LDRS SPYI QVLE EDWR QALR DHQE QANT IFSL RKDL RQGE ARRL RCME EKEM FELQ CLAL RKDS KMYK DRIE AILL QMEE VAIE RDQA IATR EELH AQHA RGLQ EKDA LRKQ VREL GEKA DELQ LQVF QCEA QLLA VEGR LRRQ QLET LVLS SDLE DGSP RRSQ ELSL PQDL EDTQ LSDK GCLA GGGS PKQP FAAL HQEQ VLRN PHDA GPAG LPGI GAVC |
| Gene ID: | 64170 |
| Uniprot: | Q9H257 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 42kDa/56kDa/62kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | CARD9: Activates NF-kappa-B via BCL10. Defects in CARD9 are the cause of familial candidiasis type 2 (CANDF2). Chronic mucocutaneous candidiasis is characterized by impaired clearance of fungal infections and results in colonization and infections of the mucosa or skin, predominantly with Candida albicans. CANDF2 is an autosomal recessive chronic mucocutaneous candidiasis. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: cytoplasm Molecular Function:protein homodimerization activity; CARD domain binding Biological Process: response to drug; response to fungus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of interleukin-2 biosynthetic process; regulation of interleukin-6 biosynthetic process; positive regulation of interleukin-6 production; positive regulation of JNK cascade; positive regulation of tumor necrosis factor production; positive regulation of stress-activated MAPK cascade; regulation of apoptosis; defense response to Gram-positive bacterium; response to exogenous dsRNA; response to muramyl dipeptide; response to peptidoglycan; innate immune response; defense response to virus; regulation of tumor necrosis factor biosynthetic process Disease: Candidiasis, Familial, 2 |
| NCBI Summary: | The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq] |
| UniProt Code: | Q9H257 |
| NCBI GenInfo Identifier: | 16554562 |
| NCBI Gene ID: | 64170 |
| NCBI Accession: | NP_434701.1 |
| UniProt Related Accession: | Q5SXM5,Q9H257 |
| Molecular Weight: | 62,241 Da |
| NCBI Full Name: | caspase recruitment domain-containing protein 9 isoform 2 |
| NCBI Synonym Full Names: | caspase recruitment domain family, member 9 |
| NCBI Official Symbol: | CARD9 |
| NCBI Official Synonym Symbols: | CANDF2; hCARD9 |
| NCBI Protein Information: | caspase recruitment domain-containing protein 9; OTTHUMP00000022569; OTTHUMP00000022571 |
| UniProt Protein Name: | Caspase recruitment domain family, member 9 |
| Protein Family: | Caspase recruitment domain-containing protein |
| UniProt Gene Name: | CARD9 |
| UniProt Entry Name: | Q5SXM5_HUMAN |
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