Cell Biology Antibodies 7
Anti-CARD16 Antibody (CAB16624)
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- SKU:
- CAB16624
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CARD16 Antibody |
| Antibody SKU: | CAB16624 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CARD16 (NP_001017534.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | mouse lung |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CARD16 (NP_001017534.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VMDK TRAL IDSV IPKG AQAC QICI TYIC EEDS YLAE TLGL SAAL QAVQ DNPA MPTC SSPE GRIK LCFL EDAQ RIWK QKLQ RCHV QNTI IKWS ERYT SGSF E |
| Gene ID: | 114769 |
| Uniprot: | Q5EG05 |
| Cellular Location: | |
| Calculated MW: | 10kDa/22kDa |
| Observed MW: | 28kDa |
| Synonyms: | CARD16, COP, COP1, PSEUDO-ICE |
| Background: |
| UniProt Protein Function: | CARD16: Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. Down-regulated in patients suffering of Huntington disease. Homooligomer. Interacts with CASP1, CASP4, CARD8 and RIPK2. 2 isoforms of the human protein are produced by alternative splicing |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q22 |
| UniProt Code: | Q5EG05 |
| NCBI GenInfo Identifier: | 74722547 |
| NCBI Gene ID: | 114769 |
| NCBI Accession: | Q5EG05.1 |
| UniProt Secondary Accession: | Q5EG05,Q96RJ9, |
| UniProt Related Accession: | Q5EG05 |
| Molecular Weight: | 10,737 Da |
| NCBI Full Name: | Caspase recruitment domain-containing protein 16 |
| NCBI Synonym Full Names: | caspase recruitment domain family member 16 |
| NCBI Official Symbol: | CARD16 |
| NCBI Official Synonym Symbols: | COP; COP1; PSEUDO-ICE |
| NCBI Protein Information: | caspase recruitment domain-containing protein 16 |
| UniProt Protein Name: | Caspase recruitment domain-containing protein 16 |
| UniProt Synonym Protein Names: | Caspase recruitment domain-only protein 1; CARD-only protein 1; Caspase-1 inhibitor COP; Pseudo interleukin-1 beta converting enzyme; Pseudo-ICE; Pseudo-IL1B-converting enzyme |
| Protein Family: | Caspase recruitment domain-containing protein |
| UniProt Gene Name: | CARD16 |
| UniProt Entry Name: | CAR16_HUMAN |
 | Western blot analysis of extracts of mouse lung, using CARD16 antibody (CAB16624) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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