Cell Biology Antibodies 9

Anti-CAPZA1 Antibody (CAB3776)

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SKU:
CAB3776
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CAPZA1 Antibody
Antibody SKU:CAB3776
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human CAPZA1 (NP_006126.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:1000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Jurkat, MCF7, HL-60, Mouse brain, Mouse kidney, Mouse lung, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human CAPZA1 (NP_006126.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MADF DDRV SDEE KVRI AAKF ITHA PPGE FNEV FNDV RLLL NNDN LLRE GAAH AFAQ YNMD QFTP VKIE GYED QVLI TEHG DLGN SRFL DPRN KISF KFDH LRKE ASDP QPEE ADGG LKSW RESC DSAL RAYV KDHY SNGF CTVY AKTI DGQQ TIIA CIES HQFQ PKNF WNGR WRSE WKFT ITPP TAQV VGVL KIQV HYYE DGNV QLVS HKDV QDSL TVSN EAQT AKEF IKII ENAE NEYQ TAIS ENYQ TMSD TTFK ALRR QLPV TRTK IDWN KILS YKIG KEMQ NA
Gene ID:829
Uniprot:P52907
Cellular Location:Cytoplasm, cytoskeleton
Calculated MW:32kDa
Observed MW:38kDa
Synonyms:CAPZA1, CAPPA1, CAPZ, CAZ1
Background:CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments.
UniProt Protein Function:CAPZA1: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Belongs to the F-actin-capping protein alpha subunit family.
UniProt Protein Details:

Protein type:Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: F-actin capping protein complex; cytoskeleton; extracellular region; cytosol; actin cytoskeleton

Molecular Function:protein binding; actin binding

Biological Process: innate immune response; protein complex assembly; cell motility; blood coagulation; barbed-end actin filament capping

NCBI Summary:CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]
UniProt Code:P52907
NCBI GenInfo Identifier:1705650
NCBI Gene ID:829
NCBI Accession:P52907.3
UniProt Secondary Accession:P52907,Q53FQ6, Q6FHD5,
UniProt Related Accession:P52907
Molecular Weight:286
NCBI Full Name:F-actin-capping protein subunit alpha-1
NCBI Synonym Full Names:capping protein (actin filament) muscle Z-line, alpha 1
NCBI Official Symbol:CAPZA1  
NCBI Official Synonym Symbols:CAPZ; CAZ1; CAPPA1  
NCBI Protein Information:F-actin-capping protein subunit alpha-1; Cap Z; capZ alpha-1
UniProt Protein Name:F-actin-capping protein subunit alpha-1
UniProt Synonym Protein Names:CapZ alpha-1
Protein Family:F-actin-capping protein
UniProt Gene Name:CAPZA1  
UniProt Entry Name:CAZA1_HUMAN
Anti-CAPZA1 Antibody (CAB3776)Western blot analysis of extracts of various cell lines, using CAPZA1 antibody (CAB3776) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
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