Developmental Biology
Anti-CAPRIN1 Antibody (CAB7910)
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- SKU:
- CAB7910
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-CAPRIN1 Antibody |
| Antibody SKU: | CAB7910 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CAPRIN1 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, HeLa, Jurkat |
| Immunogen: | Recombinant protein of human CAPRIN1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4076 |
| Uniprot: | Q14444 |
| Cellular Location: | Cell projection, Cytoplasm, cytosol, dendrite |
| Calculated MW: | 76kDa/78kDa |
| Observed MW: | 120kDa |
| Synonyms: | CAPRIN1, GPIAP1, GPIP137, GRIP137, M11S1, RNG105, p137GPI, caprin-1 |
| Background: | CAPRIN1(Caprin-1) is a cytoplasmic phosphoprotein which may regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Its levels, except in the brain, are tightly correlated with cellular proliferation. Suppression of expression of human Caprin-1 resulted in slowing of the proliferation rate, which suggests its essential for normal cellular proliferation. |
| UniProt Protein Function: | CAPRIN1: May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Belongs to the caprin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; Cell surface Chromosomal Location of Human Ortholog: 11p13 Cellular Component: membrane; stress granule; integral to plasma membrane; cytoplasm; dendrite; cytosol Molecular Function:RNA binding Biological Process: negative regulation of translation; positive regulation of dendrite morphogenesis |
| UniProt Code: | Q14444 |
| NCBI GenInfo Identifier: | 182676426 |
| NCBI Gene ID: | 4076 |
| NCBI Accession: | Q14444.2 |
| UniProt Secondary Accession: | Q14444,Q15074, Q6IMN4, Q6IMN7, Q9BV09, A6NMY7, D3DR06 |
| UniProt Related Accession: | Q14444 |
| Molecular Weight: | 709 |
| NCBI Full Name: | Caprin-1 |
| NCBI Synonym Full Names: | cell cycle associated protein 1 |
| NCBI Official Symbol: | CAPRIN1 |
| NCBI Official Synonym Symbols: | M11S1; GPIAP1; RNG105; GPIP137; GRIP137; p137GPI |
| NCBI Protein Information: | caprin-1; GPI-p137; caprin 1; RNA granule protein 105; GPI-anchored protein p137; GPI-anchored membrane protein 1; cell cycle-associated protein 1; activation/proliferation-associated protein 1; membrane component chromosome 11 surface marker 1; membrane |
| UniProt Protein Name: | Caprin-1 |
| UniProt Synonym Protein Names: | Cell cycle-associated protein 1; Cytoplasmic activation- and proliferation-associated protein 1; GPI-anchored membrane protein 1; GPI-anchored protein p137; GPI-p137; p137GPI; Membrane component chromosome 11 surface marker 1; RNA granule protein 105 |
| Protein Family: | Caprin |
| UniProt Gene Name: | CAPRIN1 |
| UniProt Entry Name: | CAPR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CAPRIN1 antibody (CAB7910) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse brain using CAPRIN1 antibody (CAB7910) (40x lens). |
 | Immunofluorescence analysis of C6 cells using CAPRIN1 Rabbit pAb (CAB7910) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using CAPRIN1 Rabbit pAb (CAB7910) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U-2 OS cells using CAPRIN1 Rabbit pAb (CAB7910) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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