Cell Biology Antibodies 4
Anti-CAP2 Antibody (CAB14358)
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- SKU:
- CAB14358
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CAP2 Antibody |
| Antibody SKU: | CAB14358 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 128-477 of human CAP2 (NP_006357.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | DU145, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 128-477 of human CAP2 (NP_006357.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NMFN HLSA VSES IPAL GWIA VSPK PGPY VKEM NDAA TFYT NRVL KDYK HSDL RHVD WVKS YLNI WSEL QAYI KEHH TTGL TWSK TGPV ASTV SAFS VLSS GPGL PPPP PPLP PPGP PPLF ENEG KKEE SSPS RSAL FAQL NQGE AITK GLRH VTDD QKTY KNPS LRAQ GGQT QSPT KSHT PSPT SPKS YPSQ KHAP VLEL EGKK WRVE YQED RNDL VISE TELK QVAY IFKC EKST IQIK GKVN SIII DNCK KLGL VFDN VVGI VEVI NSQD IQIQ VMGR VPTI SINK TEGC HIYL SEDA LDCE IVSA KSSE MNIL IPQD GDYR EFPI PEQF KTAW DGSK LITE PAEI MA |
| Gene ID: | 10486 |
| Uniprot: | P40123 |
| Cellular Location: | Cell membrane, Peripheral membrane protein |
| Calculated MW: | 24kDa/45kDa/52kDa |
| Observed MW: | 55kDa |
| Synonyms: | CAP2 |
| Background: | This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. |
| UniProt Protein Function: | CAP2: a cyclase-associated protein. CAPs are evolutionarily conserved proteins with roles in regulating the actin cytoskeleton and in signal transduction. CAP2 is expressed mainly in brain, heart and skeletal muscle, and skin. It is found in the nucleus in undifferentiated myoblasts and at the M-line of differentiated myotubes. Up-regulated in human cancers. May play a role in multistage hepatocarcinogenesis. |
| UniProt Protein Details: | Protein type:Actin-binding Chromosomal Location of Human Ortholog: 6p22.3 Cellular Component: plasma membrane Molecular Function:actin binding Biological Process: axon guidance; adenylate cyclase activation; establishment and/or maintenance of cell polarity; cytoskeleton organization and biogenesis; signal transduction |
| NCBI Summary: | This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P40123 |
| NCBI GenInfo Identifier: | 729015 |
| NCBI Gene ID: | 10486 |
| NCBI Accession: | P40123.1 |
| UniProt Secondary Accession: | P40123,Q9CYT6, P52481, |
| UniProt Related Accession: | P40123 |
| Molecular Weight: | 477 |
| NCBI Full Name: | Adenylyl cyclase-associated protein 2 |
| NCBI Synonym Full Names: | CAP, adenylate cyclase-associated protein, 2 (yeast) |
| NCBI Official Symbol: | CAP2 |
| NCBI Protein Information: | adenylyl cyclase-associated protein 2; CAP 2; 2810452G09Rik |
| UniProt Protein Name: | Adenylyl cyclase-associated protein 2 |
| Protein Family: | F-actin-capping protein |
| UniProt Gene Name: | CAP2 |
| UniProt Entry Name: | CAP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CAP2 antibody (CAB14358) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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