Cell Biology Antibodies 5

Anti-CAP1 Antibody (CAB14577)

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SKU:
CAB14577
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CAP1 Antibody
Antibody SKU:CAB14577
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CAP1 (NP_006358.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, A-431, HepG2, Rat thymus, Mouse thymus
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CAP1 (NP_006358.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MADM QNLV ERLE RAVG RLEA VSHT SDMH RGYA DSPS KAGA APYV QAFD SLLA GPVA EYLK ISKE IGGD VQKH AEMV HTGL KLER ALLV TASQ CQQP AENK
Gene ID:10487
Uniprot:Q01518
Cellular Location:Cell membrane, Peripheral membrane protein
Calculated MW:51kDa
Observed MW:60kDa
Synonyms:CAP1, CAP, CAP1-PEN
Background:The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified.
UniProt Protein Function:CAP1: an actin binding protein. Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
UniProt Protein Details:

Protein type:Actin-binding; Cytoskeletal

Chromosomal Location of Human Ortholog: 1p34.2

Cellular Component: cortical actin cytoskeleton; focal adhesion; plasma membrane

Molecular Function:actin binding

Biological Process: axon guidance; platelet activation; receptor-mediated endocytosis; platelet degranulation; ameboidal cell migration; adenylate cyclase activation; establishment and/or maintenance of cell polarity; signal transduction; blood coagulation; actin cytoskeleton organization and biogenesis

NCBI Summary:The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:Q01518
NCBI GenInfo Identifier:308153681
NCBI Gene ID:10487
NCBI Accession:Q01518.5
UniProt Secondary Accession:Q01518,P40124, Q08163,
UniProt Related Accession:Q01518
Molecular Weight:475
NCBI Full Name:Adenylyl cyclase-associated protein 1
NCBI Synonym Full Names:CAP, adenylate cyclase-associated protein 1 (yeast)
NCBI Official Symbol:CAP1  
NCBI Official Synonym Symbols:CAP; CAP1-PEN  
NCBI Protein Information:adenylyl cyclase-associated protein 1; CAP 1
UniProt Protein Name:Adenylyl cyclase-associated protein 1
Protein Family:CAP1-binding-protein
UniProt Gene Name:CAP1  
UniProt Entry Name:CAP1_HUMAN
Anti-CAP1 Antibody (CAB14577)Western blot analysis of extracts of various cell lines, using CAP1 antibody (CAB14577) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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