Cell Biology Antibodies 10
Anti-CANT1 Antibody (CAB6341)
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- SKU:
- CAB6341
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CANT1 Antibody |
| Antibody SKU: | CAB6341 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 102-401 of human CANT1 (NP_001153245.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | U-251MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 102-401 of human CANT1 (NP_001153245.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GIRY RIAV IADL DTES RAQE ENTW FSYL KKGY LTLS DSGD KVAV EWDK DHGV LESH LAEK GRGM ELSD LIVF NGKL YSVD DRTG VVYQ IEGS KAVP WVIL SDGD GTVE KGFK AEWL AVKD ERLY VGGL GKEW TTTT GDVV NENP EWVK VVGY KGSV DHEN WVSN YNAL RAAA GIQP PGYL IHES ACWS DTLQ RWFF LPRR ASQE RYSE KDDE RKGA NLLL SASP DFGD IAVS HVGA VVPT HGFS SFKF IPNT DDQI IVAL KSEE DSGR VASY IMAF TLDG RFLL PETK IGSV KYEG IEFI |
| Gene ID: | 124583 |
| Uniprot: | Q8WVQ1 |
| Cellular Location: | Endoplasmic reticulum membrane, Golgi apparatus, Golgi stack membrane, Single-pass type II membrane protein |
| Calculated MW: | 27kDa/38kDa/44kDa |
| Observed MW: | 45kDa |
| Synonyms: | CANT1, DBQD, DBQD1, SCAN-1, SCAN1, SHAPY |
| Background: | This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene. |
| UniProt Protein Function: | CANT1: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis. Defects in CANT1 are the cause of Desbuquois dysplasia (DBQD). A chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of Desbuquois dysplasia are distinguished on the basis of the presence (type 1) or absence (type 2) of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations. Belongs to the apyrase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - pyrimidine; EC 3.6.1.6; Hydrolase; Endoplasmic reticulum; Nucleotide Metabolism - purine; Membrane protein, integral Chromosomal Location of Human Ortholog: 17q25.3 Molecular Function:guanosine-diphosphatase activity; signal transducer activity; uridine-diphosphatase activity Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; proteoglycan biosynthetic process Disease: Desbuquois Dysplasia 1 |
| NCBI Summary: | This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010] |
| UniProt Code: | Q8WVQ1 |
| NCBI GenInfo Identifier: | 66774052 |
| NCBI Gene ID: | 124583 |
| NCBI Accession: | Q8WVQ1.1 |
| UniProt Secondary Accession: | Q8WVQ1,Q7Z2J7, Q8NG05, Q8NHP0, Q9BSD5, B4DJ54, |
| UniProt Related Accession: | Q8WVQ1 |
| Molecular Weight: | 38,946 Da |
| NCBI Full Name: | Soluble calcium-activated nucleotidase 1 |
| NCBI Synonym Full Names: | calcium activated nucleotidase 1 |
| NCBI Official Symbol: | CANT1 |
| NCBI Official Synonym Symbols: | DBQD; DBQD1; SCAN1; SHAPY; SCAN-1 |
| NCBI Protein Information: | soluble calcium-activated nucleotidase 1 |
| UniProt Protein Name: | Soluble calcium-activated nucleotidase 1 |
| UniProt Synonym Protein Names: | Apyrase homolog; Putative MAPK-activating protein PM09; Putative NF-kappa-B-activating protein 107 |
| Protein Family: | Soluble calcium-activated nucleotidase |
| UniProt Gene Name: | CANT1 |
| UniProt Entry Name: | CANT1_HUMAN |
 | Western blot analysis of extracts of U-251MG cells, using CANT1 antibody (CAB6341) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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