Cell Biology Antibodies 6
Anti-CAMP Antibody (CAB15653)
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- SKU:
- CAB15653
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CAMP Antibody |
| Antibody SKU: | CAB15653 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-170 of human CAMP (NP_004336.3). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, A-549, PC-3, SP2/0, mouse testis, mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-170 of human CAMP (NP_004336.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IIAQ VLSY KEAV LRAI DGIN QRSS DANL YRLL DLDP RPTM DGDP DTPK PVSF TVKE TVCP RTTQ QSPE DCDF KKDG LVKR CMGT VTLN QARG SFDI SCDK DNKR FALL GDFF RKSK EKIG KEFK RIVQ RIKD FLRN LVPR |
| Gene ID: | 820 |
| Uniprot: | P49913 |
| Cellular Location: | Secreted |
| Calculated MW: | 19kDa |
| Observed MW: | 15kDa |
| Synonyms: | CAMP, CAP-18, CAP18, CRAMP, FALL-39, FALL39, HSD26, LL37 |
| Background: | This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. |
| UniProt Protein Function: | CAMP: Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity. Belongs to the cathelicidin family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Cell cycle regulation; Vesicle; Secreted Chromosomal Location of Human Ortholog: 3p21.3 Cellular Component: cell wall; extracellular region; extracellular space; specific granule Biological Process: antibacterial humoral response; cell redox homeostasis; defense response to bacterium; defense response to Gram-positive bacterium; innate immune response in mucosa; killing by host of symbiont cells |
| NCBI Summary: | This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P49913 |
| NCBI GenInfo Identifier: | 1706745 |
| NCBI Gene ID: | 820 |
| NCBI Accession: | P49913.1 |
| UniProt Secondary Accession: | P49913,Q71SN9, |
| UniProt Related Accession: | P49913 |
| Molecular Weight: | 19,301 Da |
| NCBI Full Name: | Cathelicidin antimicrobial peptide |
| NCBI Synonym Full Names: | cathelicidin antimicrobial peptide |
| NCBI Official Symbol: | CAMP |
| NCBI Official Synonym Symbols: | LL37; CAP18; CRAMP; HSD26; CAP-18; FALL39; FALL-39 |
| NCBI Protein Information: | cathelicidin antimicrobial peptide |
| UniProt Protein Name: | Cathelicidin antimicrobial peptide |
| UniProt Synonym Protein Names: | FALL-39 peptide antibiotic |
| Protein Family: | CAMPATH-1 antigen |
| UniProt Gene Name: | CAMP |
| UniProt Entry Name: | CAMP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CAMP antibody (CAB15653) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded rat bone marrow using CAMP antibody (CAB15653) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human appendix using CAMP antibody (CAB15653) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of rat bone marrow using CAMP antibody (CAB15653) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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