ChIP Antibodies
Anti-CAMKK1 Antibody (CAB16716)
- SKU:
- CAB16716
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-CAMKK1 Antibody |
Antibody SKU: | CAB16716 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Human, Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 399-520 of human CAMKK1 (NP_757344.2). |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Reactivity: | Human, Mouse |
Positive Samples: | LO2, HeLa, A-549 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 399-520 of human CAMKK1 (NP_757344.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | LHRK IKNE PVVF PEEP EISE ELKD LILK MLDK NPET RIGV PDIK LHPW VTKN GEEP LPSE EEHC SVVE VTEE EVKN SVRL IPSW TTVI LVKS MLRK RSFG NPFE PQAR REER SMSA PGNL LV |
Gene ID: | 84254 |
Uniprot: | Q8N5S9 |
Cellular Location: | Cytoplasm, Nucleus |
Calculated MW: | 55kDa/57kDa |
Observed MW: | 56kDa |
Synonyms: | CAMKK1, CAMKKA |
Background: | The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. |
UniProt Protein Function: | CAMKK1: a calcium/calmodulin-dependent S/T protein kinase of the CAMKK family. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. 2 isoforms of the human protein are produced by alternative splicing. The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. Binding of calmodulin may releave intrasteric autoinhibition. May be regulated through phosphorylation by CAMK1 and CAMK4. Appears to be autophosphorylated in a Ca2+/calmodulin-dependent manner. Phosphorylation of Ser-458 is blocked upon binding to Ca2+/calmodulin. |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.17; Other group; CAMKK family; Meta subfamily Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: cytosol Molecular Function:calmodulin-dependent protein kinase activity; protein binding |
NCBI Summary: | The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8N5S9 |
NCBI GenInfo Identifier: | 56404620 |
NCBI Gene ID: | 84254 |
NCBI Accession: | Q8N5S9.2 |
UniProt Secondary Accession: | Q8N5S9,Q9BQH3, |
UniProt Related Accession: | Q8N5S9 |
Molecular Weight: | 57,523 Da |
NCBI Full Name: | Calcium/calmodulin-dependent protein kinase kinase 1 |
NCBI Synonym Full Names: | calcium/calmodulin dependent protein kinase kinase 1 |
NCBI Official Symbol: | CAMKK1 |
NCBI Official Synonym Symbols: | CAMKKA |
NCBI Protein Information: | calcium/calmodulin-dependent protein kinase kinase 1 |
UniProt Protein Name: | Calcium/calmodulin-dependent protein kinase kinase 1 |
UniProt Synonym Protein Names: | CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha |
Protein Family: | Calcium/calmodulin-dependent protein kinase |
UniProt Gene Name: | CAMKK1 |
UniProt Entry Name: | KKCC1_HUMAN |
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