Immunology Antibodies 1
Anti-CAMK1D Antibody (CAB13435)
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- SKU:
- CAB13435
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-CAMK1D Antibody |
| Antibody SKU: | CAB13435 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human CAMK1D (NP_705718.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human CAMK1D (NP_705718.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MARE NGES SSSW KKQA EDIK KIFE FKET LGTG AFSE VVLA EEKA TGKL FAVK CIPK KALK GKES SIEN EIAV LRKI KHEN IVAL EDIY ESPN HLYL VMQL VSGG ELFD RIVE KGFY TEKD ASTL IRQV LDAV YYLH RMGI VHRD LKPE NLLY YSQD EESK IMIS DFGL SKME GKGD VMST |
| Gene ID: | 57118 |
| Uniprot: | Q8IU85 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 40kDa/42kDa |
| Observed MW: | Refer to figures |
| Synonyms: | CAMK1D, CKLiK, CaM-K1, CaMKID |
| Background: | This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. |
| UniProt Protein Function: | CAMK1D: a calcium/calmodulin-dependent S/T protein kinase of the CAMK group. Binding of calmodulin is thought to result in a conformational change and can lead to subsequent activation through phosphorylation by CAMKK1 and CAMKK2. Can be activated by CAMKK1 in a calcium-independent manner. Its Ca(2+)/CaM-dependent activity is enhanced 30-fold in vitro by phosphorylation at Thr180 by CaMKK1. Broadly expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. May regulate calcium-mediated granulocyte function. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta and probably CREB1. Expression increases upon treatment of EC cells with DMSO and retinoic acid. Two isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 2.7.11.17; CAMK group; CAMK1 family Chromosomal Location of Human Ortholog: 10p13 Cellular Component: cytoplasm; nucleus Molecular Function:calmodulin binding; calmodulin-dependent protein kinase activity; ATP binding Biological Process: positive regulation of apoptosis; positive regulation of phagocytosis; activation of CREB transcription factor; regulation of dendrite development; inflammatory response; protein amino acid phosphorylation; negative regulation of apoptosis |
| NCBI Summary: | This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015] |
| UniProt Code: | Q8IU85 |
| NCBI GenInfo Identifier: | 56404610 |
| NCBI Gene ID: | 57118 |
| NCBI Accession: | Q8IU85.1 |
| UniProt Related Accession: | Q8IU85 |
| Molecular Weight: | 45kDa |
| NCBI Full Name: | Calcium/calmodulin-dependent protein kinase type 1D |
| NCBI Synonym Full Names: | calcium/calmodulin dependent protein kinase ID |
| NCBI Official Symbol: | CAMK1D |
| NCBI Official Synonym Symbols: | CKLiK; CaM-K1; CaMKID |
| NCBI Protein Information: | calcium/calmodulin-dependent protein kinase type 1D |
| UniProt Protein Name: | Calcium/calmodulin-dependent protein kinase type 1D |
| UniProt Synonym Protein Names: | CaM kinase I delta; CaM kinase ID; CaM-KI delta; CaMKI delta; CaMKID; CaMKI-like protein kinase; CKLiK |
| Protein Family: | Calcium/calmodulin-dependent protein kinase |
| UniProt Gene Name: | CAMK1D |
| UniProt Entry Name: | KCC1D_HUMAN |
 | Immunofluorescence analysis of A549 cells using CAMK1D antibody (CAB13435). Blue: DAPI for nuclear staining. |
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