| UniProt Protein Function: | CAMK1A: an ubiquitous protein kinase of the CAMK1 family. Activated by Ca(2+)/calmodulin. Must be phosphorylated to be maximally active. Substrates include synapsin I. |
| UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.17; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; CAMK group; CAMK1 family Chromosomal Location of Human Ortholog: 3p25.3 Cellular Component: cytoplasm; nucleus Molecular Function:calmodulin binding; protein binding; calmodulin-dependent protein kinase activity; ATP binding Biological Process: positive regulation of syncytium formation by plasma membrane fusion; regulation of muscle cell differentiation; nucleocytoplasmic transport; signal transduction; cell cycle; protein amino acid phosphorylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of synapse structural plasticity; positive regulation of protein export from nucleus; regulation of protein localization; regulation of protein binding; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein binding |
| NCBI Summary: | Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14012 |
| NCBI GenInfo Identifier: | 3122301 |
| NCBI Gene ID: | 8536 |
| NCBI Accession: | Q14012.1 |
| UniProt Secondary Accession: | Q14012,Q3KPF6, |
| UniProt Related Accession: | Q14012 |
| Molecular Weight: | 370 |
| NCBI Full Name: | Calcium/calmodulin-dependent protein kinase type 1 |
| NCBI Synonym Full Names: | calcium/calmodulin-dependent protein kinase I |
| NCBI Official Symbol: | CAMK1 |
| NCBI Official Synonym Symbols: | CAMKI |
| NCBI Protein Information: | calcium/calmodulin-dependent protein kinase type 1; caM-KI; caMKI-alpha; caM kinase I alpha |
| UniProt Protein Name: | Calcium/calmodulin-dependent protein kinase type 1 |
| UniProt Synonym Protein Names: | CaM kinase I; CaM-KI; CaM kinase I alpha; CaMKI-alpha |
| Protein Family: | Calcium/calmodulin-dependent serine/threonine-protein kinase |
| UniProt Gene Name: | CAMK1 |
| UniProt Entry Name: | KCC1A_HUMAN |
