Cell Cycle Antibodies 1
Anti-CAMK1 Antibody (CAB14495)
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- SKU:
- CAB14495
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-CAMK1 Antibody |
| Antibody SKU: | CAB14495 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-93 of human CAMK1 (NP_003647.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse lung, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-93 of human CAMK1 (NP_003647.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLGA VEGP RWKQ AEDI RDIY DFRD VLGT GAFS EVIL AEDK RTQK LVAI KCIA KEAL EGKE GSME NEIA VLHK IKHP NIVA LDDI YESG GHLY L |
| Gene ID: | 8536 |
| Uniprot: | Q14012 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 41kDa |
| Observed MW: | 41kDa |
| Synonyms: | CAMK1, CAMKI |
| Background: | Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. |
| UniProt Protein Function: | CAMK1A: an ubiquitous protein kinase of the CAMK1 family. Activated by Ca(2+)/calmodulin. Must be phosphorylated to be maximally active. Substrates include synapsin I. |
| UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.17; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; CAMK group; CAMK1 family Chromosomal Location of Human Ortholog: 3p25.3 Cellular Component: cytoplasm; nucleus Molecular Function:calmodulin binding; protein binding; calmodulin-dependent protein kinase activity; ATP binding Biological Process: positive regulation of syncytium formation by plasma membrane fusion; regulation of muscle cell differentiation; nucleocytoplasmic transport; signal transduction; cell cycle; protein amino acid phosphorylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of synapse structural plasticity; positive regulation of protein export from nucleus; regulation of protein localization; regulation of protein binding; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein binding |
| NCBI Summary: | Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14012 |
| NCBI GenInfo Identifier: | 3122301 |
| NCBI Gene ID: | 8536 |
| NCBI Accession: | Q14012.1 |
| UniProt Secondary Accession: | Q14012,Q3KPF6, |
| UniProt Related Accession: | Q14012 |
| Molecular Weight: | 370 |
| NCBI Full Name: | Calcium/calmodulin-dependent protein kinase type 1 |
| NCBI Synonym Full Names: | calcium/calmodulin-dependent protein kinase I |
| NCBI Official Symbol: | CAMK1 |
| NCBI Official Synonym Symbols: | CAMKI |
| NCBI Protein Information: | calcium/calmodulin-dependent protein kinase type 1; caM-KI; caMKI-alpha; caM kinase I alpha |
| UniProt Protein Name: | Calcium/calmodulin-dependent protein kinase type 1 |
| UniProt Synonym Protein Names: | CaM kinase I; CaM-KI; CaM kinase I alpha; CaMKI-alpha |
| Protein Family: | Calcium/calmodulin-dependent serine/threonine-protein kinase |
| UniProt Gene Name: | CAMK1 |
| UniProt Entry Name: | KCC1A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CAMK1 antibody (CAB14495) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human stomach using CAMK1 antibody (CAB14495) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using CAMK1 antibody (CAB14495) at dilution of 1:100 (40x lens). |
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system_update_altDatasheetHuman CAMK1/CaMKI-alpha Recombinant Protein Calcium/Calmodulin-Dependent Protein Kinase Type 1 (CAMK1) belongs to the protein kinase superfamily, CAMK Ser/Thr protein ki