Cell Biology Antibodies 3
Anti-CALU Antibody (CAB12408)
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- SKU:
- CAB12408
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CALU Antibody |
| Antibody SKU: | CAB12408 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-315 of human CALU (NP_001210.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NCI-H460, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-315 of human CALU (NP_001210.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KPTE KKDR VHHE PQLS DKVH NDAQ SFDY DHDA FLGA EEAK TFDQ LTPE ESKE RLGK IVSK IDGD KDGF VTVD ELKD WIKF AQKR WIYE DVER QWKG HDLN EDGL VSWE EYKN ATYG YVLD DPDP DDGF NYKQ MMVR DERR FKMA DKDG DLIA TKEE FTAF LHPE EYDY MKDI VVQE TMED IDKN ADGF IDLE EYIG DMYS HDGN TDEP EWVK TERE QFVE FRDK NRDG KMDK EETK DWIL PSDY DHAE AEAR HLVY ESDQ NKDG KLTK EEIV DKYD LFVG SQAT DFGE ALVR HDEF |
| Gene ID: | 813 |
| Uniprot: | O43852 |
| Cellular Location: | Endoplasmic reticulum lumen, Melanosome, Sarcoplasmic reticulum lumen, Secreted |
| Calculated MW: | 8kDa/16-38kDa |
| Observed MW: | 47kDa |
| Synonyms: | CALU, calumenin |
| Background: | The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | CALU: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity. Belongs to the CREC family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Calcium-binding; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7q32.1 Cellular Component: endoplasmic reticulum; membrane Molecular Function:calcium ion binding; protein binding |
| NCBI Summary: | The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008] |
| UniProt Code: | O43852 |
| NCBI GenInfo Identifier: | 5921197 |
| NCBI Gene ID: | 813 |
| NCBI Accession: | O43852.2 |
| UniProt Secondary Accession: | O43852,B3KPG9, D6QS48, D6QS49, D6QS50, D6QS51, D6QS52 D6QS53, D6QS54, D6QS55, D6QS56, D6QS57, |
| UniProt Related Accession: | O43852 |
| Molecular Weight: | 37kDa |
| NCBI Full Name: | Calumenin |
| NCBI Synonym Full Names: | calumenin |
| NCBI Official Symbol: | CALU |
| NCBI Protein Information: | calumenin |
| UniProt Protein Name: | Calumenin |
| UniProt Synonym Protein Names: | Crocalbin; IEF SSP 9302 |
| Protein Family: | Calumenin |
| UniProt Gene Name: | CALU |
 | Western blot analysis of extracts of various cell lines, using CALU antibody (CAB12408) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of HeLa cells using CALU antibody (CAB12408). Blue: DAPI for nuclear staining. |
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