Cell Biology Antibodies 17
Anti-Calpain 1 Antibody (CAB8710)
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- SKU:
- CAB8710
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Calpain 1 Antibody |
| Antibody SKU: | CAB8710 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Calpain 1 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-431, U-937, Mouse kidney |
| Immunogen: | A synthesized peptide derived from human Calpain 1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 823 |
| Uniprot: | P07384 |
| Cellular Location: | |
| Calculated MW: | 75, 80kDa |
| Observed MW: | 75KDa |
| Synonyms: | CANP, CANP1, CANPL1, SPG76, muCANP, muCL |
| Background: | The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
| UniProt Protein Function: | CAPN1: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Ubiquitous. Activated by micromolar concentrations of calcium and inhibited by calpastatin. Belongs to the peptidase C2 family. |
| UniProt Protein Details: | Protein type:EC 3.4.22.52; Protease; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q13 Cellular Component: focal adhesion; membrane; cytoplasm; plasma membrane; cytosol Molecular Function:protein binding; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; receptor catabolic process; positive regulation of cell proliferation; proteolysis |
| NCBI Summary: | The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
| UniProt Code: | P07384 |
| NCBI GenInfo Identifier: | 115574 |
| NCBI Gene ID: | 823 |
| NCBI Accession: | P07384.1 |
| UniProt Secondary Accession: | P07384,Q2TTR0, Q6DHV4, |
| UniProt Related Accession: | P07384 |
| Molecular Weight: | |
| NCBI Full Name: | Calpain-1 catalytic subunit |
| NCBI Synonym Full Names: | calpain 1, (mu/I) large subunit |
| NCBI Official Symbol: | CAPN1 |
| NCBI Official Synonym Symbols: | CANP; muCL; CANP1; CANPL1; muCANP |
| NCBI Protein Information: | calpain-1 catalytic subunit; CANP 1; calpain mu-type; micromolar-calpain; calpain-1 large subunit; calpain, large polypeptide L1; calcium-activated neutral proteinase 1; cell proliferation-inducing protein 30; cell proliferation-inducing gene 30 protein |
| UniProt Protein Name: | Calpain-1 catalytic subunit |
| UniProt Synonym Protein Names: | Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; Calpain-1 large subunit; Cell proliferation-inducing gene 30 protein; Micromolar-calpain; muCANP |
| Protein Family: | Calpain |
| UniProt Gene Name: | CAPN1 |
| UniProt Entry Name: | CAN1_HUMAN |
 | Western blot - Calpain 1 Rabbit mAb (CAB8710) |
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