Immunology Antibodies 3
Anti-Calnexin Antibody (CAB4846)
- SKU:
- CAB4846
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CNX
- Synonyms:
- IP90
- Synonyms:
- P90
- Synonyms:
- CANX
- Research Area:
- Immunology
Description
| Product Name: | Calnexin Rabbit mAb |
| Product Code: | CAB4846 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CNX, IP90, P90, Calnexin, CANX, calnexin |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Calnexin |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, HepG2, K-562 |
| Immunogen: | A synthesized peptide derived from human Calnexin |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 821 |
| Uniprot: | P27824 |
| Cellular Location: | Endoplasmic reticulum, Endoplasmic reticulum membrane, Melanosome, Single-pass type I membrane protein |
| Calculated MW: | 90kDa |
| Observed MW: | 90kDa |
| UniProt Protein Function: | Calnexin: a calcium-binding protein of the calreticulin family. A type I membrane protein of the endoplasmic reticulum.Interacts with newly synthesized glycoproteins in the endoplasmic reticulum. May act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; Calcium-binding; Motility/polarity/chemotaxis; Membrane protein, integral Chromosomal Location of Human Ortholog: 5q35 Cellular Component: dendrite cytoplasm; endoplasmic reticulum membrane; protein complex; smooth endoplasmic reticulum; rough endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum; dendritic spine; cell soma; membrane; axon; melanosome; ribosome Molecular Function:ionotropic glutamate receptor binding; protein binding; unfolded protein binding; apolipoprotein binding; calcium ion binding; carbohydrate binding; glycoprotein binding Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; protein folding; synaptic vesicle endocytosis; protein secretion; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; aging |
| NCBI Summary: | This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P27824 |
| NCBI GenInfo Identifier: | 543920 |
| NCBI Gene ID: | 821 |
| NCBI Accession: | P27824.2 |
| UniProt Secondary Accession: | P27824,B2R5V8, B4DGP8, B4E2T8, D3DWQ3, D6R9K3, |
| UniProt Related Accession: | P27824 |
| Molecular Weight: | 55,598 Da |
| NCBI Full Name: | Calnexin |
| NCBI Synonym Full Names: | calnexin |
| NCBI Official Symbol: | CANX |
| NCBI Official Synonym Symbols: | CNX; P90; IP90 |
| NCBI Protein Information: | calnexin; major histocompatibility complex class I antigen-binding protein p88 |
| UniProt Protein Name: | Calnexin |
| UniProt Synonym Protein Names: | IP90; Major histocompatibility complex class I antigen-binding protein p88; p90 |
| UniProt Gene Name: | CANX |
| UniProt Entry Name: | CALX_HUMAN |
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