Cell Biology Antibodies 11

Anti-CALM2 Antibody (CAB8008)

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SKU:
CAB8008
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:CALM2 Rabbit Polyclonal Antibody
Antibody SKU:CAB8008
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-149 of human CALM2 (NP_001734.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:NIH/3T3, MCF7, BT-474, NCI-H460, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-149 of human CALM2 (NP_001734.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MADQ LTEE QIAE FKEA FSLF DKDG DGTI TTKE LGTV MRSL GQNP TEAE LQDM INEV DADG NGTI DFPE FLTM MARK MKDT DSEE EIRE AFRV FDKD GNGY ISAA ELRH VMTN LGEK LTDE EVDE MIRE ADID GDGQ VNYE EFVQ MMTA K
Gene ID:805
Uniprot:P62158
Cellular Location:Cytoplasm, cytoskeleton, spindle, spindle pole
Calculated MW:17kDa
Observed MW:17kDa
Synonyms:CALM2, CAMII, LQT15, PHKD, PHKD2, caM
Background:This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms.
NCBI Summary:This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
UniProt Code:P62158
NCBI GenInfo Identifier:49037474
NCBI Gene ID:801
NCBI Accession:P62158.2
UniProt Related Accession:P0DP23
Molecular Weight:
NCBI Full Name:
NCBI Synonym Full Names:calmodulin 1
NCBI Official Symbol:CALM1  
NCBI Official Synonym Symbols:caM; CAMI; PHKD; CPVT4; DD132; LQT14; CALML2  
NCBI Protein Information:calmodulin-1
UniProt Protein Name:
Protein Family:Calmodulin
UniProt Gene Name:
Anti-CALM2 Polyclonal Antibody (CAB8008)Western blot analysis of extracts of various cell lines, using CALM2 antibody (CAB8008) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (RM00020)._Exposure time: 30s.
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