Cell Biology Antibodies 11

Anti-CALHM1 Antibody (CAB7858)

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SKU:
CAB7858
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CALHM1 Antibody
Antibody SKU:CAB7858
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 202-346 of human CALHM1 (NP_001001412.3).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:SH-SY5Y, HepG2, U-87MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 202-346 of human CALHM1 (NP_001001412.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VRSV RPCF TQAA FLKS KYWS HYID IERK LFDE TCTE HAKA FAKV CIQQ FFEA MNHD LELG HTHG TLAT APAS AAAP TTPD GAEE EREK LRGI TDQG TMNR LLTS WHKC KPPL RLGQ EEPP LMGN GWAG GGPR PPRK EVAT YFSK V
Gene ID:255022
Uniprot:Q8IU99
Cellular Location:Cell membrane, Endoplasmic reticulum membrane, Multi-pass membrane protein
Calculated MW:38kDa
Observed MW:45kDa
Synonyms:CALHM1, FAM26C
Background:This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.
UniProt Protein Function:CALHM1: May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner. Belongs to the FAM26 family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium

Chromosomal Location of Human Ortholog: 10q24.33

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane

Molecular Function:calcium activated cation channel activity; identical protein binding; voltage-gated calcium channel activity; voltage-gated ion channel activity

Biological Process: ATP transport; cation transport; protein homooligomerization; sensory perception of bitter taste; sensory perception of sweet taste; sensory perception of umami taste

NCBI Summary:This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010]
UniProt Code:Q8IU99
NCBI GenInfo Identifier:68565595
NCBI Gene ID:255022
NCBI Accession:Q8IU99.2
UniProt Secondary Accession:Q8IU99,Q5W091,
UniProt Related Accession:Q8IU99
Molecular Weight:38,264 Da
NCBI Full Name:Calcium homeostasis modulator protein 1
NCBI Synonym Full Names:calcium homeostasis modulator 1
NCBI Official Symbol:CALHM1  
NCBI Official Synonym Symbols:FAM26C  
NCBI Protein Information:calcium homeostasis modulator protein 1
UniProt Protein Name:Calcium homeostasis modulator protein 1
UniProt Synonym Protein Names:Protein FAM26C
Protein Family:Calcium homeostasis modulator protein
UniProt Gene Name:CALHM1  
UniProt Entry Name:CAHM1_HUMAN
Anti-CALHM1 Antibody (CAB7858)Western blot analysis of extracts of various cell lines, using CALHM1 antibody (CAB7858) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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